Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear

In this issue of Cell, Korber et al. found that a SARS-CoV-2 variant in the spike protein D614G rapidly became dominant around the world. Although clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeut...

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Detalles Bibliográficos
Autores principales: Grubaugh, Nathan D., Hanage, William P., Rasmussen, Angela L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332445/
https://www.ncbi.nlm.nih.gov/pubmed/32697970
http://dx.doi.org/10.1016/j.cell.2020.06.040
Descripción
Sumario:In this issue of Cell, Korber et al. found that a SARS-CoV-2 variant in the spike protein D614G rapidly became dominant around the world. Although clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeutic development are largely unknown.

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