Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear

In this issue of Cell, Korber et al. found that a SARS-CoV-2 variant in the spike protein D614G rapidly became dominant around the world. Although clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeut...

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Detalles Bibliográficos
Autores principales: Grubaugh, Nathan D., Hanage, William P., Rasmussen, Angela L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332445/
https://www.ncbi.nlm.nih.gov/pubmed/32697970
http://dx.doi.org/10.1016/j.cell.2020.06.040
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author Grubaugh, Nathan D.
Hanage, William P.
Rasmussen, Angela L.
author_facet Grubaugh, Nathan D.
Hanage, William P.
Rasmussen, Angela L.
author_sort Grubaugh, Nathan D.
collection PubMed
description In this issue of Cell, Korber et al. found that a SARS-CoV-2 variant in the spike protein D614G rapidly became dominant around the world. Although clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeutic development are largely unknown.
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spelling pubmed-73324452020-07-06 Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear Grubaugh, Nathan D. Hanage, William P. Rasmussen, Angela L. Cell Article In this issue of Cell, Korber et al. found that a SARS-CoV-2 variant in the spike protein D614G rapidly became dominant around the world. Although clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeutic development are largely unknown. Elsevier Inc. 2020-08-20 2020-07-03 /pmc/articles/PMC7332445/ /pubmed/32697970 http://dx.doi.org/10.1016/j.cell.2020.06.040 Text en © 2020 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Grubaugh, Nathan D.
Hanage, William P.
Rasmussen, Angela L.
Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear
title Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear
title_full Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear
title_fullStr Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear
title_full_unstemmed Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear
title_short Making Sense of Mutation: What D614G Means for the COVID-19 Pandemic Remains Unclear
title_sort making sense of mutation: what d614g means for the covid-19 pandemic remains unclear
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332445/
https://www.ncbi.nlm.nih.gov/pubmed/32697970
http://dx.doi.org/10.1016/j.cell.2020.06.040
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