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COVID-19: Clinical aspects and therapeutics responses

COVID-19 has created havoc in the world by causing thousands of demises in a short period of time. Up till now, several attempts have been made for potential therapeutics against SARS-COV2. In this retrospective, single-center study, we extracted data from 122 COVID-19, RT-PCR confirmed patients. wh...

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Autores principales: Khan, Suliman, Ali, Ashaq, Shi, Hongwei, Siddique, Rabeea, Shabana, Nabi, Ghulam, Hu, Junjie, Wang, Tiejun, Dong, Men, Zaman, Wajid, Han, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332461/
https://www.ncbi.nlm.nih.gov/pubmed/32788835
http://dx.doi.org/10.1016/j.jsps.2020.06.022
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author Khan, Suliman
Ali, Ashaq
Shi, Hongwei
Siddique, Rabeea
Shabana
Nabi, Ghulam
Hu, Junjie
Wang, Tiejun
Dong, Men
Zaman, Wajid
Han, Guang
author_facet Khan, Suliman
Ali, Ashaq
Shi, Hongwei
Siddique, Rabeea
Shabana
Nabi, Ghulam
Hu, Junjie
Wang, Tiejun
Dong, Men
Zaman, Wajid
Han, Guang
author_sort Khan, Suliman
collection PubMed
description COVID-19 has created havoc in the world by causing thousands of demises in a short period of time. Up till now, several attempts have been made for potential therapeutics against SARS-COV2. In this retrospective, single-center study, we extracted data from 122 COVID-19, RT-PCR confirmed patients. who were treated with a new treatment strategy of lianhuaqingwen with Arbidol Hydrochloride. The patients were either asymptomatic or had mild symptoms for COVID-19 disease. Of 122 patients 21 (17.21%) patients developed severe conditions of COVID-19, while total 111 (90.9%) experienced mild symptoms such as fever in 93 (76.22%) patients, cough in 23 (20.17%) and muscle pain were observed in total 8 (7%) patients. Furthermore our newly applied drugs combination (Lianhuaqingwen and Arbidol Hydrochloride) showed therapeutic effects in 5–7 days in patients with mild symptoms with 98% recovery rate. These results indicate that COVID-19 patients with mild symptoms can be treated with Lianhuaqingwen and Arbidol Hydrochloride. However, extensive clinical investigations are required to confirm the effectiveness of these drugs.
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spelling pubmed-73324612020-07-06 COVID-19: Clinical aspects and therapeutics responses Khan, Suliman Ali, Ashaq Shi, Hongwei Siddique, Rabeea Shabana Nabi, Ghulam Hu, Junjie Wang, Tiejun Dong, Men Zaman, Wajid Han, Guang Saudi Pharm J Article COVID-19 has created havoc in the world by causing thousands of demises in a short period of time. Up till now, several attempts have been made for potential therapeutics against SARS-COV2. In this retrospective, single-center study, we extracted data from 122 COVID-19, RT-PCR confirmed patients. who were treated with a new treatment strategy of lianhuaqingwen with Arbidol Hydrochloride. The patients were either asymptomatic or had mild symptoms for COVID-19 disease. Of 122 patients 21 (17.21%) patients developed severe conditions of COVID-19, while total 111 (90.9%) experienced mild symptoms such as fever in 93 (76.22%) patients, cough in 23 (20.17%) and muscle pain were observed in total 8 (7%) patients. Furthermore our newly applied drugs combination (Lianhuaqingwen and Arbidol Hydrochloride) showed therapeutic effects in 5–7 days in patients with mild symptoms with 98% recovery rate. These results indicate that COVID-19 patients with mild symptoms can be treated with Lianhuaqingwen and Arbidol Hydrochloride. However, extensive clinical investigations are required to confirm the effectiveness of these drugs. Elsevier 2020-08 2020-07-03 /pmc/articles/PMC7332461/ /pubmed/32788835 http://dx.doi.org/10.1016/j.jsps.2020.06.022 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Khan, Suliman
Ali, Ashaq
Shi, Hongwei
Siddique, Rabeea
Shabana
Nabi, Ghulam
Hu, Junjie
Wang, Tiejun
Dong, Men
Zaman, Wajid
Han, Guang
COVID-19: Clinical aspects and therapeutics responses
title COVID-19: Clinical aspects and therapeutics responses
title_full COVID-19: Clinical aspects and therapeutics responses
title_fullStr COVID-19: Clinical aspects and therapeutics responses
title_full_unstemmed COVID-19: Clinical aspects and therapeutics responses
title_short COVID-19: Clinical aspects and therapeutics responses
title_sort covid-19: clinical aspects and therapeutics responses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332461/
https://www.ncbi.nlm.nih.gov/pubmed/32788835
http://dx.doi.org/10.1016/j.jsps.2020.06.022
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