Current Evidences and Future Perspectives for AMPK in the Regulation of Milk Production and Mammary Gland Biology

Activated protein kinase (AMP)-activated protein kinase (AMPK) senses the cellular energy status and coordinates catabolic and anabolic processes. Extensive studies have proposed that AMPK regulates energy homeostasis, cell growth, autophagy, mitochondrial biology and inflammation. The biological fu...

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Autores principales: Wu, Zhihui, Tian, Min, Heng, Jinghui, Chen, Jiaming, Chen, Fang, Guan, Wutai, Zhang, Shihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332552/
https://www.ncbi.nlm.nih.gov/pubmed/32671074
http://dx.doi.org/10.3389/fcell.2020.00530
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author Wu, Zhihui
Tian, Min
Heng, Jinghui
Chen, Jiaming
Chen, Fang
Guan, Wutai
Zhang, Shihai
author_facet Wu, Zhihui
Tian, Min
Heng, Jinghui
Chen, Jiaming
Chen, Fang
Guan, Wutai
Zhang, Shihai
author_sort Wu, Zhihui
collection PubMed
description Activated protein kinase (AMP)-activated protein kinase (AMPK) senses the cellular energy status and coordinates catabolic and anabolic processes. Extensive studies have proposed that AMPK regulates energy homeostasis, cell growth, autophagy, mitochondrial biology and inflammation. The biological functions of AMPK vary in different tissues or organs. As a unique organ that produces milk, the mammary gland has recently attracted substantial research attention. This review discusses how AMPK in the mammary gland is activated by energy deprivation and heat stress via the activation of canonical and non-canonical pathways. In addition, the important downstream targets of AMPK and their functions in the mammary gland, especially during milk synthesis, are summarized in the review.
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spelling pubmed-73325522020-07-14 Current Evidences and Future Perspectives for AMPK in the Regulation of Milk Production and Mammary Gland Biology Wu, Zhihui Tian, Min Heng, Jinghui Chen, Jiaming Chen, Fang Guan, Wutai Zhang, Shihai Front Cell Dev Biol Cell and Developmental Biology Activated protein kinase (AMP)-activated protein kinase (AMPK) senses the cellular energy status and coordinates catabolic and anabolic processes. Extensive studies have proposed that AMPK regulates energy homeostasis, cell growth, autophagy, mitochondrial biology and inflammation. The biological functions of AMPK vary in different tissues or organs. As a unique organ that produces milk, the mammary gland has recently attracted substantial research attention. This review discusses how AMPK in the mammary gland is activated by energy deprivation and heat stress via the activation of canonical and non-canonical pathways. In addition, the important downstream targets of AMPK and their functions in the mammary gland, especially during milk synthesis, are summarized in the review. Frontiers Media S.A. 2020-06-26 /pmc/articles/PMC7332552/ /pubmed/32671074 http://dx.doi.org/10.3389/fcell.2020.00530 Text en Copyright © 2020 Wu, Tian, Heng, Chen, Chen, Guan and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Wu, Zhihui
Tian, Min
Heng, Jinghui
Chen, Jiaming
Chen, Fang
Guan, Wutai
Zhang, Shihai
Current Evidences and Future Perspectives for AMPK in the Regulation of Milk Production and Mammary Gland Biology
title Current Evidences and Future Perspectives for AMPK in the Regulation of Milk Production and Mammary Gland Biology
title_full Current Evidences and Future Perspectives for AMPK in the Regulation of Milk Production and Mammary Gland Biology
title_fullStr Current Evidences and Future Perspectives for AMPK in the Regulation of Milk Production and Mammary Gland Biology
title_full_unstemmed Current Evidences and Future Perspectives for AMPK in the Regulation of Milk Production and Mammary Gland Biology
title_short Current Evidences and Future Perspectives for AMPK in the Regulation of Milk Production and Mammary Gland Biology
title_sort current evidences and future perspectives for ampk in the regulation of milk production and mammary gland biology
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332552/
https://www.ncbi.nlm.nih.gov/pubmed/32671074
http://dx.doi.org/10.3389/fcell.2020.00530
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