Cargando…

PathWalks: identifying pathway communities using a disease-related map of integrated information

MOTIVATION: Understanding the underlying biological mechanisms and respective interactions of a disease remains an elusive, time consuming and costly task. Computational methodologies that propose pathway/mechanism communities and reveal respective relationships can be of great value as they can hel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Karatzas, Evangelos, Zachariou, Margarita, Bourdakou, Marilena M, Minadakis, George, Oulas, Anastasis, Kolios, George, Delis, Alex, Spyrou, George M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332569/ https://www.ncbi.nlm.nih.gov/pubmed/32369599 http://dx.doi.org/10.1093/bioinformatics/btaa291

Ejemplares similares

Systems Bioinformatics: increasing precision of computational diagnostics and therapeutics through network-based approaches
por: Oulas, Anastasis, et al.
Publicado: (2017)

Generalized linear models provide a measure of virulence for specific mutations in SARS-CoV-2 strains
por: Oulas, Anastasis, et al.
Publicado: (2021)

PathwayConnector: finding complementary pathways to enhance functional analysis
por: Minadakis, George, et al.
Publicado: (2019)

Selecting variants of unknown significance through network-based gene-association significantly improves risk prediction for disease-control cohorts
por: Oulas, Anastasis, et al.
Publicado: (2019)

A Web Tool for Ranking Candidate Drugs Against a Selected Disease Based on a Combination of Functional and Structural Criteria
por: Karatzas, Evangelos, et al.
Publicado: (2019)

Bacterial Wars—a tool for the prediction of bacterial predominance based on network analysis measures
por: Oulas, Anastasis, et al.
Publicado: (2023)

Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19
por: Tomazou, Marios, et al.
Publicado: (2021)

Informed walks: whispering hints to gene hunters inside networks’ jungle
por: Bourdakou, Marilena M., et al.
Publicado: (2017)

Fibrotic expression profile analysis reveals repurposed drugs with potential anti-fibrotic mode of action
por: Karatzas, Evangelos, et al.
Publicado: (2021)

Network-based stage-specific drug repurposing for Alzheimer’s disease
por: Savva, Kyriaki, et al.
Publicado: (2022)

Drug repurposing in idiopathic pulmonary fibrosis filtered by a bioinformatics-derived composite score
por: Karatzas, E., et al.
Publicado: (2017)

PathIN: an integrated tool for the visualization of pathway interaction networks()
por: Minadakis, George, et al.
Publicado: (2022)

Putative Antimicrobial Peptides Within Bacterial Proteomes Affect Bacterial Predominance: A Network Analysis Perspective
por: Oulas, Anastasis, et al.
Publicado: (2021)

Analyzing Gene Expression Profiles from Ataxia and Spasticity Phenotypes to Reveal Spastic Ataxia Related Pathways
por: Kakouri, Andrea C., et al.
Publicado: (2020)

GeneStoryTeller: a mobile app for quick and comprehensive information retrieval of human genes
por: Eleftheriou, Stergiani V., et al.
Publicado: (2015)

Beyond the Backbone: The Next Generation of Pathwalking Utilities for Model Building in CryoEM Density Maps
por: Hryc, Corey F., et al.
Publicado: (2022)

PathExNET: A tool for extracting pathway expression networks from gene expression statistics
por: Minadakis, George, et al.
Publicado: (2021)

In Silico Identification of Antimicrobial Peptides in the Proteomes of Goat and Sheep Milk and Feta Cheese
por: Tomazou, Marios, et al.
Publicado: (2019)

Discovering gene re-ranking efficiency and conserved gene-gene relationships derived from gene co-expression network analysis on breast cancer data
por: Bourdakou, Marilena M., et al.
Publicado: (2016)

Investigating the Transition of Pre-Symptomatic to Symptomatic Huntington’s Disease Status Based on Omics Data
por: Christodoulou, Christiana C., et al.
Publicado: (2020)

Drug repurposing on Alzheimer's disease through modulation of NRF2 neighborhood
por: Bourdakou, Marilena M., et al.
Publicado: (2023)

Novel clinical, molecular and bioinformatics insights into the genetic background of autism
por: Talli, Ioanna, et al.
Publicado: (2022)

ProtExA: A tool for post-processing proteomics data providing differential expression metrics, co-expression networks and functional analytics
por: Minadakis, George, et al.
Publicado: (2020)

In depth analysis of Cyprus-specific mutations of SARS-CoV-2 strains using computational approaches
por: Oulas, Anastasis, et al.
Publicado: (2021)

Vir2Drug: a drug repurposing framework based on protein similarities between pathogens
por: Minadakis, George, et al.
Publicado: (2022)

Niclosamide Attenuates Inflammation-Associated Profibrotic Responses in Human Subepithelial Lung Myofibroblasts
por: Spathakis, Michail, et al.
Publicado: (2023)

Neurophysiological and Genetic Findings in Patients With Juvenile Myoclonic Epilepsy
por: Stefani, Stefani, et al.
Publicado: (2020)

Inhibition of Breast Cancer Cell Invasion by Ras Suppressor-1 (RSU-1) Silencing Is Reversed by Growth Differentiation Factor-15 (GDF-15)
por: Gkretsi, Vasiliki, et al.
Publicado: (2019)

Comparative analysis of affected and unaffected areas of systemic sclerosis skin biopsies by high-throughput proteomic approaches
por: Chairta, Paraskevi, et al.
Publicado: (2020)

ChemBioServer 2.0: an advanced web server for filtering, clustering and networking of chemical compounds facilitating both drug discovery and repurposing
por: Karatzas, Evangelos, et al.
Publicado: (2020)

Dysbiosis and Enhanced Beta-Defensin Production in Hair Follicles of Patients with Lichen Planopilaris and Frontal Fibrosing Alopecia
por: Constantinou, Andria, et al.
Publicado: (2021)

GnRH Deficient Patients With Congenital Hypogonadotropic Hypogonadism: Novel Genetic Findings in ANOS1, RNF216, WDR11, FGFR1, CHD7, and POLR3A Genes in a Case Series and Review of the Literature
por: Neocleous, Vassos, et al.
Publicado: (2020)

Molecular epidemiology of SARS-CoV-2 in Cyprus
por: Richter, Jan, et al.
Publicado: (2021)

Exploring microbial functional biodiversity at the protein family level—From metagenomic sequence reads to annotated protein clusters
por: Baltoumas, Fotis A., et al.
Publicado: (2023)

A Web-based database of genetic association studies in cutaneous melanoma enhanced with network-driven data exploration tools
por: Athanasiadis, Emmanouil I., et al.
Publicado: (2014)

Differential genetic and functional background in inflammatory bowel disease phenotypes of a Greek population: a systems bioinformatics approach
por: Gazouli, Maria, et al.
Publicado: (2019)

Age-Related Exosomal and Endogenous Expression Patterns of miR-1, miR-133a, miR-133b, and miR-206 in Skeletal Muscles
por: Mytidou, Chrystalla, et al.
Publicado: (2021)

Preliminary In Vitro and In Vivo Insights of In Silico Candidate Repurposed Drugs for Alzheimer’s Disease
por: Savva, Kyriaki, et al.
Publicado: (2023)

Transcriptomic characterization of tissues from patients and subsequent pathway analyses reveal biological pathways that are implicated in spastic ataxia
por: Kakouri, Andrea C., et al.
Publicado: (2022)

Circulating small RNA signatures differentiate accurately the subtypes of muscular dystrophies: small-RNA next-generation sequencing analytics and functional insights
por: Kakouri, Andrea C., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_dn37c0ufm3obutorj4tp0meudo