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Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival
We herein report a 66-year-old woman with advanced lung adenocarcinoma [programmed cell death and its ligand 1 (PD-L1) tumor proportion score 60%] lacking driver oncogenes in whom meningeal carcinomatosis, along with sudden onset dizziness, deafness, and consciousness disturbance, appeared after sec...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332633/ https://www.ncbi.nlm.nih.gov/pubmed/32161221 http://dx.doi.org/10.2169/internalmedicine.4232-19 |
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author | Nakashima, Koki Demura, Yoshiki Oi, Masahiro Tabata, Mio Tada, Toshihiko Shiozaki, Kohei Akai, Masaya Ishizuka, Tamotsu |
author_facet | Nakashima, Koki Demura, Yoshiki Oi, Masahiro Tabata, Mio Tada, Toshihiko Shiozaki, Kohei Akai, Masaya Ishizuka, Tamotsu |
author_sort | Nakashima, Koki |
collection | PubMed |
description | We herein report a 66-year-old woman with advanced lung adenocarcinoma [programmed cell death and its ligand 1 (PD-L1) tumor proportion score 60%] lacking driver oncogenes in whom meningeal carcinomatosis, along with sudden onset dizziness, deafness, and consciousness disturbance, appeared after second-line chemotherapy. Whole-brain radiation therapy (WBRT) and Pembrolizumab were subsequently administered, and third-line chemotherapy with Pembrolizumab is now ongoing. At the time of writing, the patient has achieved a 23-month survival without disease progression. Our findings suggest that the combination of WBRT and an immune checkpoint inhibitor is effective for non-small-cell lung cancer patients lacking driver oncogenes who develop meningeal carcinomatosis. |
format | Online Article Text |
id | pubmed-7332633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-73326332020-08-03 Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival Nakashima, Koki Demura, Yoshiki Oi, Masahiro Tabata, Mio Tada, Toshihiko Shiozaki, Kohei Akai, Masaya Ishizuka, Tamotsu Intern Med Case Report We herein report a 66-year-old woman with advanced lung adenocarcinoma [programmed cell death and its ligand 1 (PD-L1) tumor proportion score 60%] lacking driver oncogenes in whom meningeal carcinomatosis, along with sudden onset dizziness, deafness, and consciousness disturbance, appeared after second-line chemotherapy. Whole-brain radiation therapy (WBRT) and Pembrolizumab were subsequently administered, and third-line chemotherapy with Pembrolizumab is now ongoing. At the time of writing, the patient has achieved a 23-month survival without disease progression. Our findings suggest that the combination of WBRT and an immune checkpoint inhibitor is effective for non-small-cell lung cancer patients lacking driver oncogenes who develop meningeal carcinomatosis. The Japanese Society of Internal Medicine 2020-03-12 2020-06-01 /pmc/articles/PMC7332633/ /pubmed/32161221 http://dx.doi.org/10.2169/internalmedicine.4232-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Nakashima, Koki Demura, Yoshiki Oi, Masahiro Tabata, Mio Tada, Toshihiko Shiozaki, Kohei Akai, Masaya Ishizuka, Tamotsu Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival |
title | Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival |
title_full | Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival |
title_fullStr | Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival |
title_full_unstemmed | Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival |
title_short | Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival |
title_sort | whole-brain radiation and pembrolizumab treatment for a non-small-cell lung cancer patient with meningeal carcinomatosis lacking driver oncogenes led to a long-term survival |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332633/ https://www.ncbi.nlm.nih.gov/pubmed/32161221 http://dx.doi.org/10.2169/internalmedicine.4232-19 |
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