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Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival

We herein report a 66-year-old woman with advanced lung adenocarcinoma [programmed cell death and its ligand 1 (PD-L1) tumor proportion score 60%] lacking driver oncogenes in whom meningeal carcinomatosis, along with sudden onset dizziness, deafness, and consciousness disturbance, appeared after sec...

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Autores principales: Nakashima, Koki, Demura, Yoshiki, Oi, Masahiro, Tabata, Mio, Tada, Toshihiko, Shiozaki, Kohei, Akai, Masaya, Ishizuka, Tamotsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332633/
https://www.ncbi.nlm.nih.gov/pubmed/32161221
http://dx.doi.org/10.2169/internalmedicine.4232-19
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author Nakashima, Koki
Demura, Yoshiki
Oi, Masahiro
Tabata, Mio
Tada, Toshihiko
Shiozaki, Kohei
Akai, Masaya
Ishizuka, Tamotsu
author_facet Nakashima, Koki
Demura, Yoshiki
Oi, Masahiro
Tabata, Mio
Tada, Toshihiko
Shiozaki, Kohei
Akai, Masaya
Ishizuka, Tamotsu
author_sort Nakashima, Koki
collection PubMed
description We herein report a 66-year-old woman with advanced lung adenocarcinoma [programmed cell death and its ligand 1 (PD-L1) tumor proportion score 60%] lacking driver oncogenes in whom meningeal carcinomatosis, along with sudden onset dizziness, deafness, and consciousness disturbance, appeared after second-line chemotherapy. Whole-brain radiation therapy (WBRT) and Pembrolizumab were subsequently administered, and third-line chemotherapy with Pembrolizumab is now ongoing. At the time of writing, the patient has achieved a 23-month survival without disease progression. Our findings suggest that the combination of WBRT and an immune checkpoint inhibitor is effective for non-small-cell lung cancer patients lacking driver oncogenes who develop meningeal carcinomatosis.
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spelling pubmed-73326332020-08-03 Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival Nakashima, Koki Demura, Yoshiki Oi, Masahiro Tabata, Mio Tada, Toshihiko Shiozaki, Kohei Akai, Masaya Ishizuka, Tamotsu Intern Med Case Report We herein report a 66-year-old woman with advanced lung adenocarcinoma [programmed cell death and its ligand 1 (PD-L1) tumor proportion score 60%] lacking driver oncogenes in whom meningeal carcinomatosis, along with sudden onset dizziness, deafness, and consciousness disturbance, appeared after second-line chemotherapy. Whole-brain radiation therapy (WBRT) and Pembrolizumab were subsequently administered, and third-line chemotherapy with Pembrolizumab is now ongoing. At the time of writing, the patient has achieved a 23-month survival without disease progression. Our findings suggest that the combination of WBRT and an immune checkpoint inhibitor is effective for non-small-cell lung cancer patients lacking driver oncogenes who develop meningeal carcinomatosis. The Japanese Society of Internal Medicine 2020-03-12 2020-06-01 /pmc/articles/PMC7332633/ /pubmed/32161221 http://dx.doi.org/10.2169/internalmedicine.4232-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nakashima, Koki
Demura, Yoshiki
Oi, Masahiro
Tabata, Mio
Tada, Toshihiko
Shiozaki, Kohei
Akai, Masaya
Ishizuka, Tamotsu
Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival
title Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival
title_full Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival
title_fullStr Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival
title_full_unstemmed Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival
title_short Whole-brain Radiation and Pembrolizumab Treatment for a Non-small-cell Lung Cancer Patient with Meningeal Carcinomatosis Lacking Driver Oncogenes Led to a Long-term Survival
title_sort whole-brain radiation and pembrolizumab treatment for a non-small-cell lung cancer patient with meningeal carcinomatosis lacking driver oncogenes led to a long-term survival
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332633/
https://www.ncbi.nlm.nih.gov/pubmed/32161221
http://dx.doi.org/10.2169/internalmedicine.4232-19
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