IgG4-related Autoimmune Hepatitis with a Suspected Drug-induced Etiology

A 69-year-old man was referred to our department with acute hepatitis. He had been newly treated with benidipine hydrochloride for two months. His blood test results were as follows: aspartate aminotransferase, 1,614 IU/L; alanine aminotransferase, 1,091 IU/L and anti-smooth muscle antibody, ×80. Ne...

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Autores principales: Kawabata, Hideaki, Kawakatsu, Yukino, Inoue, Naonori, Okazaki, Yuji, Sone, Daiki, Yamaguchi, Katsutoshi, Ueda, Yuki, Hitomi, Misuzu, Miyata, Masatoshi, Motoi, Shigehiro, Enoki, Yasuyuki, Minamikawa, Tetsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332635/
https://www.ncbi.nlm.nih.gov/pubmed/32475907
http://dx.doi.org/10.2169/internalmedicine.4092-19
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author Kawabata, Hideaki
Kawakatsu, Yukino
Inoue, Naonori
Okazaki, Yuji
Sone, Daiki
Yamaguchi, Katsutoshi
Ueda, Yuki
Hitomi, Misuzu
Miyata, Masatoshi
Motoi, Shigehiro
Enoki, Yasuyuki
Minamikawa, Tetsuhiro
author_facet Kawabata, Hideaki
Kawakatsu, Yukino
Inoue, Naonori
Okazaki, Yuji
Sone, Daiki
Yamaguchi, Katsutoshi
Ueda, Yuki
Hitomi, Misuzu
Miyata, Masatoshi
Motoi, Shigehiro
Enoki, Yasuyuki
Minamikawa, Tetsuhiro
author_sort Kawabata, Hideaki
collection PubMed
description A 69-year-old man was referred to our department with acute hepatitis. He had been newly treated with benidipine hydrochloride for two months. His blood test results were as follows: aspartate aminotransferase, 1,614 IU/L; alanine aminotransferase, 1,091 IU/L and anti-smooth muscle antibody, ×80. Needle liver biopsy specimen showed interface hepatitis with mainly lymphocytic infiltration and bridging fibrosis in the periportal area. Immunohistochemistry revealed lymphocytic infiltration positive for IgG4. We diagnosed him with IgG4-related AIH with an etiology that was suspected of being drug-induced. Oral prednisolone was started and then tapered after achieving biochemical remission. Hepatitis recurred after the cessation of steroids; however, remission was achieved with ursodeoxycholic acid.
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spelling pubmed-73326352020-08-03 IgG4-related Autoimmune Hepatitis with a Suspected Drug-induced Etiology Kawabata, Hideaki Kawakatsu, Yukino Inoue, Naonori Okazaki, Yuji Sone, Daiki Yamaguchi, Katsutoshi Ueda, Yuki Hitomi, Misuzu Miyata, Masatoshi Motoi, Shigehiro Enoki, Yasuyuki Minamikawa, Tetsuhiro Intern Med Case Report A 69-year-old man was referred to our department with acute hepatitis. He had been newly treated with benidipine hydrochloride for two months. His blood test results were as follows: aspartate aminotransferase, 1,614 IU/L; alanine aminotransferase, 1,091 IU/L and anti-smooth muscle antibody, ×80. Needle liver biopsy specimen showed interface hepatitis with mainly lymphocytic infiltration and bridging fibrosis in the periportal area. Immunohistochemistry revealed lymphocytic infiltration positive for IgG4. We diagnosed him with IgG4-related AIH with an etiology that was suspected of being drug-induced. Oral prednisolone was started and then tapered after achieving biochemical remission. Hepatitis recurred after the cessation of steroids; however, remission was achieved with ursodeoxycholic acid. The Japanese Society of Internal Medicine 2020-06-01 2020-06-01 /pmc/articles/PMC7332635/ /pubmed/32475907 http://dx.doi.org/10.2169/internalmedicine.4092-19 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kawabata, Hideaki
Kawakatsu, Yukino
Inoue, Naonori
Okazaki, Yuji
Sone, Daiki
Yamaguchi, Katsutoshi
Ueda, Yuki
Hitomi, Misuzu
Miyata, Masatoshi
Motoi, Shigehiro
Enoki, Yasuyuki
Minamikawa, Tetsuhiro
IgG4-related Autoimmune Hepatitis with a Suspected Drug-induced Etiology
title IgG4-related Autoimmune Hepatitis with a Suspected Drug-induced Etiology
title_full IgG4-related Autoimmune Hepatitis with a Suspected Drug-induced Etiology
title_fullStr IgG4-related Autoimmune Hepatitis with a Suspected Drug-induced Etiology
title_full_unstemmed IgG4-related Autoimmune Hepatitis with a Suspected Drug-induced Etiology
title_short IgG4-related Autoimmune Hepatitis with a Suspected Drug-induced Etiology
title_sort igg4-related autoimmune hepatitis with a suspected drug-induced etiology
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332635/
https://www.ncbi.nlm.nih.gov/pubmed/32475907
http://dx.doi.org/10.2169/internalmedicine.4092-19
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