Oxaliplatin-Induced Lhermitte's Sign in Gastric Cancer

A 64-year-old Japanese man with no significant medical history presented with epigastric discomfort of 2-weeks' duration. He was diagnosed with metastatic HER2-positive gastric cancer. Chemotherapy with capecitabine, oxaliplatin, and trastuzumab was initiated. During the eighth cycle, he sudden...

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Detalles Bibliográficos
Autores principales: Okamoto, Takeshi, Takagi, Koichi, Fukuda, Katsuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333045/
https://www.ncbi.nlm.nih.gov/pubmed/32670652
http://dx.doi.org/10.1155/2020/8826657
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author Okamoto, Takeshi
Takagi, Koichi
Fukuda, Katsuyuki
author_facet Okamoto, Takeshi
Takagi, Koichi
Fukuda, Katsuyuki
author_sort Okamoto, Takeshi
collection PubMed
description A 64-year-old Japanese man with no significant medical history presented with epigastric discomfort of 2-weeks' duration. He was diagnosed with metastatic HER2-positive gastric cancer. Chemotherapy with capecitabine, oxaliplatin, and trastuzumab was initiated. During the eighth cycle, he suddenly complained of electric shock-like pain in both legs upon neck flexion, consistent with Lhermitte's sign. Oxaliplatin was discontinued, and Lhermitte's sign resolved after 3 months. Neurotoxicity is commonly observed in platinum-based chemotherapy, but Lhermitte's sign is rare. This is the first report of oxaliplatin-induced Lhermitte's sign in a gastric cancer patient.
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spelling pubmed-73330452020-07-14 Oxaliplatin-Induced Lhermitte's Sign in Gastric Cancer Okamoto, Takeshi Takagi, Koichi Fukuda, Katsuyuki Case Rep Oncol Med Case Report A 64-year-old Japanese man with no significant medical history presented with epigastric discomfort of 2-weeks' duration. He was diagnosed with metastatic HER2-positive gastric cancer. Chemotherapy with capecitabine, oxaliplatin, and trastuzumab was initiated. During the eighth cycle, he suddenly complained of electric shock-like pain in both legs upon neck flexion, consistent with Lhermitte's sign. Oxaliplatin was discontinued, and Lhermitte's sign resolved after 3 months. Neurotoxicity is commonly observed in platinum-based chemotherapy, but Lhermitte's sign is rare. This is the first report of oxaliplatin-induced Lhermitte's sign in a gastric cancer patient. Hindawi 2020-06-24 /pmc/articles/PMC7333045/ /pubmed/32670652 http://dx.doi.org/10.1155/2020/8826657 Text en Copyright © 2020 Takeshi Okamoto et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Okamoto, Takeshi
Takagi, Koichi
Fukuda, Katsuyuki
Oxaliplatin-Induced Lhermitte's Sign in Gastric Cancer
title Oxaliplatin-Induced Lhermitte's Sign in Gastric Cancer
title_full Oxaliplatin-Induced Lhermitte's Sign in Gastric Cancer
title_fullStr Oxaliplatin-Induced Lhermitte's Sign in Gastric Cancer
title_full_unstemmed Oxaliplatin-Induced Lhermitte's Sign in Gastric Cancer
title_short Oxaliplatin-Induced Lhermitte's Sign in Gastric Cancer
title_sort oxaliplatin-induced lhermitte's sign in gastric cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333045/
https://www.ncbi.nlm.nih.gov/pubmed/32670652
http://dx.doi.org/10.1155/2020/8826657
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AT takagikoichi oxaliplatininducedlhermittessigningastriccancer
AT fukudakatsuyuki oxaliplatininducedlhermittessigningastriccancer

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