Cargando…
Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study
INTRODUCTION: Periprocedural myocardial necrosis, which can range from a low level elevation of cardiac biomarkers to a large myocardial infarction (MI), is a common complication after percutaneous coronary intervention (PCI). AIM: We hypothesized that insulin-like growth factor-1 (IGF-1) levels may...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333205/ https://www.ncbi.nlm.nih.gov/pubmed/32636900 http://dx.doi.org/10.5114/aic.2020.96059 |
_version_ | 1783553702937755648 |
---|---|
author | Tasar, Onur Kocabay, Gonenc Karabag, Yavuz Karabay, Arzu Kalayci Karabay, Can Yucel Kalkan, Sedat Kirma, Cevat |
author_facet | Tasar, Onur Kocabay, Gonenc Karabag, Yavuz Karabay, Arzu Kalayci Karabay, Can Yucel Kalkan, Sedat Kirma, Cevat |
author_sort | Tasar, Onur |
collection | PubMed |
description | INTRODUCTION: Periprocedural myocardial necrosis, which can range from a low level elevation of cardiac biomarkers to a large myocardial infarction (MI), is a common complication after percutaneous coronary intervention (PCI). AIM: We hypothesized that insulin-like growth factor-1 (IGF-1) levels may play a protective role in myocardial injury after coronary stent placement and aimed to investigate the relationship between IGF-1 levels and plaque characteristics assessed by optical coherence tomography (OCT). MATERIAL AND METHODS: Between May 2015 and December 2015 we prospectively enrolled 74 patients with stable angina pectoris in whom single de novo coronary artery stenosis was present. PCI was performed according to standard methods. OCT was applied to all patients. TnT was analyzed at admission, before PCI and at 6, 12, 24 and 48 h after PCI. Serum IGF-1 was measured prior to PCI. RESULTS: A total of 25 (33.7%) patients had periprocedural myocardial injury or type 4a myocardial infarction, and 49 (66.2%) patients had no events. IGF-1 level and reference intimal thickness, medial thickness, and plaque fibrous cap thickness in OCT had strong correlations (r = 0.88, 0.80 and 0.88 respectively, p < 0.001). IGF-1 was an independent predictor of periprocedural myocardial injury or type 4a MI in univariate (OR = 0.929, 95% CI: 0.895–0.964, p < 0.001) and multivariate regression analysis (OR = 0.757, 95% CI: 0.575–0.998, p = 0.04). Based on ROC analysis, the best cut-off value of IGF-1 for predicting periprocedural myocardial injury or type 4a myocardial infarction was 144.5 ng/ml, with a maximum sensitivity of 88% and specificity of 77.6% (AUC = 0.80, 95% CI: 0.69–0.88, p < 0.0001). CONCLUSIONS: The results from this study indicate that low IGF-1 levels are associated with plaque instability assessed by OCT. Low IGF-1 levels may identify patients who are at increased risk for periprocedural myocardial injury/infarction. |
format | Online Article Text |
id | pubmed-7333205 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-73332052020-07-06 Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study Tasar, Onur Kocabay, Gonenc Karabag, Yavuz Karabay, Arzu Kalayci Karabay, Can Yucel Kalkan, Sedat Kirma, Cevat Postepy Kardiol Interwencyjnej Original Paper INTRODUCTION: Periprocedural myocardial necrosis, which can range from a low level elevation of cardiac biomarkers to a large myocardial infarction (MI), is a common complication after percutaneous coronary intervention (PCI). AIM: We hypothesized that insulin-like growth factor-1 (IGF-1) levels may play a protective role in myocardial injury after coronary stent placement and aimed to investigate the relationship between IGF-1 levels and plaque characteristics assessed by optical coherence tomography (OCT). MATERIAL AND METHODS: Between May 2015 and December 2015 we prospectively enrolled 74 patients with stable angina pectoris in whom single de novo coronary artery stenosis was present. PCI was performed according to standard methods. OCT was applied to all patients. TnT was analyzed at admission, before PCI and at 6, 12, 24 and 48 h after PCI. Serum IGF-1 was measured prior to PCI. RESULTS: A total of 25 (33.7%) patients had periprocedural myocardial injury or type 4a myocardial infarction, and 49 (66.2%) patients had no events. IGF-1 level and reference intimal thickness, medial thickness, and plaque fibrous cap thickness in OCT had strong correlations (r = 0.88, 0.80 and 0.88 respectively, p < 0.001). IGF-1 was an independent predictor of periprocedural myocardial injury or type 4a MI in univariate (OR = 0.929, 95% CI: 0.895–0.964, p < 0.001) and multivariate regression analysis (OR = 0.757, 95% CI: 0.575–0.998, p = 0.04). Based on ROC analysis, the best cut-off value of IGF-1 for predicting periprocedural myocardial injury or type 4a myocardial infarction was 144.5 ng/ml, with a maximum sensitivity of 88% and specificity of 77.6% (AUC = 0.80, 95% CI: 0.69–0.88, p < 0.0001). CONCLUSIONS: The results from this study indicate that low IGF-1 levels are associated with plaque instability assessed by OCT. Low IGF-1 levels may identify patients who are at increased risk for periprocedural myocardial injury/infarction. Termedia Publishing House 2020-06-23 2020-06 /pmc/articles/PMC7333205/ /pubmed/32636900 http://dx.doi.org/10.5114/aic.2020.96059 Text en Copyright: © 2020 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Paper Tasar, Onur Kocabay, Gonenc Karabag, Yavuz Karabay, Arzu Kalayci Karabay, Can Yucel Kalkan, Sedat Kirma, Cevat Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study |
title | Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study |
title_full | Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study |
title_fullStr | Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study |
title_full_unstemmed | Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study |
title_short | Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study |
title_sort | insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333205/ https://www.ncbi.nlm.nih.gov/pubmed/32636900 http://dx.doi.org/10.5114/aic.2020.96059 |
work_keys_str_mv | AT tasaronur insulinlikegrowthfactor1levelspredictmyocardialinjuryandinfarctionafterelectivepercutaneouscoronaryinterventionanopticalcoherencetomographystudy AT kocabaygonenc insulinlikegrowthfactor1levelspredictmyocardialinjuryandinfarctionafterelectivepercutaneouscoronaryinterventionanopticalcoherencetomographystudy AT karabagyavuz insulinlikegrowthfactor1levelspredictmyocardialinjuryandinfarctionafterelectivepercutaneouscoronaryinterventionanopticalcoherencetomographystudy AT karabayarzukalayci insulinlikegrowthfactor1levelspredictmyocardialinjuryandinfarctionafterelectivepercutaneouscoronaryinterventionanopticalcoherencetomographystudy AT karabaycanyucel insulinlikegrowthfactor1levelspredictmyocardialinjuryandinfarctionafterelectivepercutaneouscoronaryinterventionanopticalcoherencetomographystudy AT kalkansedat insulinlikegrowthfactor1levelspredictmyocardialinjuryandinfarctionafterelectivepercutaneouscoronaryinterventionanopticalcoherencetomographystudy AT kirmacevat insulinlikegrowthfactor1levelspredictmyocardialinjuryandinfarctionafterelectivepercutaneouscoronaryinterventionanopticalcoherencetomographystudy |