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Creation and validation of a bladder dysfunction symptom score for HTLV-1-associated myelopathy/tropical spastic paraparesis
BACKGROUND: Urinary dysfunction is one of the main features of human T-cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). However, a comprehensive assessment of the severity is difficult because a standardized assessment measure is unavailable. Therefore, this s...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333329/ https://www.ncbi.nlm.nih.gov/pubmed/32620176 http://dx.doi.org/10.1186/s13023-020-01451-3 |
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author | Yamakawa, Natsuko Yagishita, Naoko Matsuo, Tomohiro Yamauchi, Junji Ueno, Takahiko Inoue, Eisuke Takata, Ayako Nagasaka, Misako Araya, Natsumi Hasegawa, Daisuke Coler-Reilly, Ariella Tsutsumi, Shuntaro Sato, Tomoo Araujo, Abelardo Casseb, Jorge Gotuzzo, Eduardo Jacobson, Steven Martin, Fabiola Puccioni-Sohler, Marzia Taylor, Graham P. Yamano, Yoshihisa |
author_facet | Yamakawa, Natsuko Yagishita, Naoko Matsuo, Tomohiro Yamauchi, Junji Ueno, Takahiko Inoue, Eisuke Takata, Ayako Nagasaka, Misako Araya, Natsumi Hasegawa, Daisuke Coler-Reilly, Ariella Tsutsumi, Shuntaro Sato, Tomoo Araujo, Abelardo Casseb, Jorge Gotuzzo, Eduardo Jacobson, Steven Martin, Fabiola Puccioni-Sohler, Marzia Taylor, Graham P. Yamano, Yoshihisa |
author_sort | Yamakawa, Natsuko |
collection | PubMed |
description | BACKGROUND: Urinary dysfunction is one of the main features of human T-cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). However, a comprehensive assessment of the severity is difficult because a standardized assessment measure is unavailable. Therefore, this study aimed to develop a novel symptom score for the assessment of urinary dysfunction in HAM/TSP. We interviewed 449 patients with HAM/TSP using four internationally validated questionnaires for assessment of urinary symptoms (27 question items in total): the International Prostate Symptom Score; the International Consultation on Incontinence Questionnaire-Short Form; the Overactive Bladder Symptom Score; and the Nocturia Quality-of-Life questionnaire. We developed a symptom score based on the data of 322 patients who did not use urinary catheters by selecting question items from questionnaires focused on descriptive statistics, correlation analysis, and exploratory factor analysis. The score distribution, reliability, and validity of the developed score were evaluated. RESULTS: First, 16 questions related to quality of life, situations, or subjective assessment were omitted from the 27 questions. Exploratory factor analysis revealed that the remaining 11 questions pertained to three factors: frequent urination, urinary incontinence, and voiding symptoms. Three questions, which had similar questions with larger factor loading, were deleted. Finally, we selected eight question items for inclusion in the novel score. The score distribution exhibited no ceiling or floor effect. The Cronbach’s alpha (0.737) demonstrated reliable internal consistency. The new score comprised two subscales with acceptable factorial validity (inter-factor correlation coefficient, 0.322): storage symptoms (frequent urination plus urinary incontinence) and voiding symptoms. The correlation between each item and the subscales suggested acceptable construct validity. CONCLUSIONS: We developed a novel score, the HAM/TSP-Bladder Dysfunction Symptom Score, and demonstrated its reliability and validity. The applicability of this score to patients using catheters should be examined in future research. |
format | Online Article Text |
id | pubmed-7333329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-73333292020-07-06 Creation and validation of a bladder dysfunction symptom score for HTLV-1-associated myelopathy/tropical spastic paraparesis Yamakawa, Natsuko Yagishita, Naoko Matsuo, Tomohiro Yamauchi, Junji Ueno, Takahiko Inoue, Eisuke Takata, Ayako Nagasaka, Misako Araya, Natsumi Hasegawa, Daisuke Coler-Reilly, Ariella Tsutsumi, Shuntaro Sato, Tomoo Araujo, Abelardo Casseb, Jorge Gotuzzo, Eduardo Jacobson, Steven Martin, Fabiola Puccioni-Sohler, Marzia Taylor, Graham P. Yamano, Yoshihisa Orphanet J Rare Dis Research BACKGROUND: Urinary dysfunction is one of the main features of human T-cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). However, a comprehensive assessment of the severity is difficult because a standardized assessment measure is unavailable. Therefore, this study aimed to develop a novel symptom score for the assessment of urinary dysfunction in HAM/TSP. We interviewed 449 patients with HAM/TSP using four internationally validated questionnaires for assessment of urinary symptoms (27 question items in total): the International Prostate Symptom Score; the International Consultation on Incontinence Questionnaire-Short Form; the Overactive Bladder Symptom Score; and the Nocturia Quality-of-Life questionnaire. We developed a symptom score based on the data of 322 patients who did not use urinary catheters by selecting question items from questionnaires focused on descriptive statistics, correlation analysis, and exploratory factor analysis. The score distribution, reliability, and validity of the developed score were evaluated. RESULTS: First, 16 questions related to quality of life, situations, or subjective assessment were omitted from the 27 questions. Exploratory factor analysis revealed that the remaining 11 questions pertained to three factors: frequent urination, urinary incontinence, and voiding symptoms. Three questions, which had similar questions with larger factor loading, were deleted. Finally, we selected eight question items for inclusion in the novel score. The score distribution exhibited no ceiling or floor effect. The Cronbach’s alpha (0.737) demonstrated reliable internal consistency. The new score comprised two subscales with acceptable factorial validity (inter-factor correlation coefficient, 0.322): storage symptoms (frequent urination plus urinary incontinence) and voiding symptoms. The correlation between each item and the subscales suggested acceptable construct validity. CONCLUSIONS: We developed a novel score, the HAM/TSP-Bladder Dysfunction Symptom Score, and demonstrated its reliability and validity. The applicability of this score to patients using catheters should be examined in future research. BioMed Central 2020-07-03 /pmc/articles/PMC7333329/ /pubmed/32620176 http://dx.doi.org/10.1186/s13023-020-01451-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Yamakawa, Natsuko Yagishita, Naoko Matsuo, Tomohiro Yamauchi, Junji Ueno, Takahiko Inoue, Eisuke Takata, Ayako Nagasaka, Misako Araya, Natsumi Hasegawa, Daisuke Coler-Reilly, Ariella Tsutsumi, Shuntaro Sato, Tomoo Araujo, Abelardo Casseb, Jorge Gotuzzo, Eduardo Jacobson, Steven Martin, Fabiola Puccioni-Sohler, Marzia Taylor, Graham P. Yamano, Yoshihisa Creation and validation of a bladder dysfunction symptom score for HTLV-1-associated myelopathy/tropical spastic paraparesis |
title | Creation and validation of a bladder dysfunction symptom score for HTLV-1-associated myelopathy/tropical spastic paraparesis |
title_full | Creation and validation of a bladder dysfunction symptom score for HTLV-1-associated myelopathy/tropical spastic paraparesis |
title_fullStr | Creation and validation of a bladder dysfunction symptom score for HTLV-1-associated myelopathy/tropical spastic paraparesis |
title_full_unstemmed | Creation and validation of a bladder dysfunction symptom score for HTLV-1-associated myelopathy/tropical spastic paraparesis |
title_short | Creation and validation of a bladder dysfunction symptom score for HTLV-1-associated myelopathy/tropical spastic paraparesis |
title_sort | creation and validation of a bladder dysfunction symptom score for htlv-1-associated myelopathy/tropical spastic paraparesis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333329/ https://www.ncbi.nlm.nih.gov/pubmed/32620176 http://dx.doi.org/10.1186/s13023-020-01451-3 |
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