Advances in methods for atomic resolution macromolecular structure determination

Recent technical advances have dramatically increased the power and scope of structural biology. New developments in high-resolution cryo-electron microscopy, serial X-ray crystallography, and electron diffraction have been especially transformative. Here we highlight some of the latest advances and...

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Detalles Bibliográficos
Autores principales: Thompson, Michael C., Yeates, Todd O., Rodriguez, Jose A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333361/
https://www.ncbi.nlm.nih.gov/pubmed/32676184
http://dx.doi.org/10.12688/f1000research.25097.1
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author Thompson, Michael C.
Yeates, Todd O.
Rodriguez, Jose A.
author_facet Thompson, Michael C.
Yeates, Todd O.
Rodriguez, Jose A.
author_sort Thompson, Michael C.
collection PubMed
description Recent technical advances have dramatically increased the power and scope of structural biology. New developments in high-resolution cryo-electron microscopy, serial X-ray crystallography, and electron diffraction have been especially transformative. Here we highlight some of the latest advances and current challenges at the frontiers of atomic resolution methods for elucidating the structures and dynamical properties of macromolecules and their complexes.
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spelling pubmed-73333612020-07-15 Advances in methods for atomic resolution macromolecular structure determination Thompson, Michael C. Yeates, Todd O. Rodriguez, Jose A. F1000Res Review Recent technical advances have dramatically increased the power and scope of structural biology. New developments in high-resolution cryo-electron microscopy, serial X-ray crystallography, and electron diffraction have been especially transformative. Here we highlight some of the latest advances and current challenges at the frontiers of atomic resolution methods for elucidating the structures and dynamical properties of macromolecules and their complexes. F1000 Research Limited 2020-07-02 /pmc/articles/PMC7333361/ /pubmed/32676184 http://dx.doi.org/10.12688/f1000research.25097.1 Text en Copyright: © 2020 Thompson MC et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Thompson, Michael C.
Yeates, Todd O.
Rodriguez, Jose A.
Advances in methods for atomic resolution macromolecular structure determination
title Advances in methods for atomic resolution macromolecular structure determination
title_full Advances in methods for atomic resolution macromolecular structure determination
title_fullStr Advances in methods for atomic resolution macromolecular structure determination
title_full_unstemmed Advances in methods for atomic resolution macromolecular structure determination
title_short Advances in methods for atomic resolution macromolecular structure determination
title_sort advances in methods for atomic resolution macromolecular structure determination
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333361/
https://www.ncbi.nlm.nih.gov/pubmed/32676184
http://dx.doi.org/10.12688/f1000research.25097.1
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