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Methotrexate impaired in-vivo matured mouse oocyte quality and the possible mechanisms
BACKGROUND: Methotrexate (MTX) is an antifolate agent which is widely used in clinic for treating malignancies, rheumatoid arthritis and ectopic pregnancy. As reported, MTX has side effects on gastrointestinal system, nervous system and reproductive system, while its potential damages on oocyte qual...
Autores principales: | Tian, Ning, Lv, Dan-yu, Yu, Ji, Ma, Wan-yun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333412/ https://www.ncbi.nlm.nih.gov/pubmed/32620073 http://dx.doi.org/10.1186/s12860-020-00298-7 |
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