Lathosterol Oxidase (Sterol C-5 Desaturase) Deletion Confers Resistance to Amphotericin B and Sensitivity to Acidic Stress in Leishmania major

Lathosterol oxidase (LSO) catalyzes the formation of the C-5–C-6 double bond in the synthesis of various types of sterols in mammals, fungi, plants, and protozoa. In Leishmania parasites, mutations in LSO or other sterol biosynthetic genes are associated with amphotericin B resistance. To investigat...

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Detalles Bibliográficos
Autores principales: Ning, Yu, Frankfater, Cheryl, Hsu, Fong-Fu, Soares, Rodrigo P., Cardoso, Camila A., Nogueira, Paula M., Lander, Noelia Marina, Docampo, Roberto, Zhang, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333571/
https://www.ncbi.nlm.nih.gov/pubmed/32611698
http://dx.doi.org/10.1128/mSphere.00380-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333571/
https://www.ncbi.nlm.nih.gov/pubmed/32611698
http://dx.doi.org/10.1128/mSphere.00380-20

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