The Effects of YAP and Its Related Mechanisms in Central Nervous System Diseases

Yes-associated protein (YAP) is a key effector downstream of the Hippo signaling pathway and plays an important role in the development of the physiology and pathology of the central nervous system (CNS), especially regulating cell proliferation, differentiation, migration, and apoptosis. However, t...

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Detalles Bibliográficos
Autores principales: Jin, Jiayan, Zhao, Xiaoxuan, Fu, Huifang, Gao, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333666/
https://www.ncbi.nlm.nih.gov/pubmed/32676008
http://dx.doi.org/10.3389/fnins.2020.00595
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author Jin, Jiayan
Zhao, Xiaoxuan
Fu, Huifang
Gao, Yuan
author_facet Jin, Jiayan
Zhao, Xiaoxuan
Fu, Huifang
Gao, Yuan
author_sort Jin, Jiayan
collection PubMed
description Yes-associated protein (YAP) is a key effector downstream of the Hippo signaling pathway and plays an important role in the development of the physiology and pathology of the central nervous system (CNS), especially regulating cell proliferation, differentiation, migration, and apoptosis. However, the roles and underlying mechanisms of YAP in CNS diseases are still puzzling. Here, this review will systematically and comprehensively summarize the biological feature, pathological role, and underlying mechanisms of YAP in normal and pathologic CNS, which aims to provide insights into the potential molecular targets and new therapeutic strategies for CNS diseases.
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spelling pubmed-73336662020-07-15 The Effects of YAP and Its Related Mechanisms in Central Nervous System Diseases Jin, Jiayan Zhao, Xiaoxuan Fu, Huifang Gao, Yuan Front Neurosci Neuroscience Yes-associated protein (YAP) is a key effector downstream of the Hippo signaling pathway and plays an important role in the development of the physiology and pathology of the central nervous system (CNS), especially regulating cell proliferation, differentiation, migration, and apoptosis. However, the roles and underlying mechanisms of YAP in CNS diseases are still puzzling. Here, this review will systematically and comprehensively summarize the biological feature, pathological role, and underlying mechanisms of YAP in normal and pathologic CNS, which aims to provide insights into the potential molecular targets and new therapeutic strategies for CNS diseases. Frontiers Media S.A. 2020-06-26 /pmc/articles/PMC7333666/ /pubmed/32676008 http://dx.doi.org/10.3389/fnins.2020.00595 Text en Copyright © 2020 Jin, Zhao, Fu and Gao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Jin, Jiayan
Zhao, Xiaoxuan
Fu, Huifang
Gao, Yuan
The Effects of YAP and Its Related Mechanisms in Central Nervous System Diseases
title The Effects of YAP and Its Related Mechanisms in Central Nervous System Diseases
title_full The Effects of YAP and Its Related Mechanisms in Central Nervous System Diseases
title_fullStr The Effects of YAP and Its Related Mechanisms in Central Nervous System Diseases
title_full_unstemmed The Effects of YAP and Its Related Mechanisms in Central Nervous System Diseases
title_short The Effects of YAP and Its Related Mechanisms in Central Nervous System Diseases
title_sort effects of yap and its related mechanisms in central nervous system diseases
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333666/
https://www.ncbi.nlm.nih.gov/pubmed/32676008
http://dx.doi.org/10.3389/fnins.2020.00595
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