Cargando…
Incidence and risk factors of type 2 diabetes mellitus in an overweight and obese population: a long-term retrospective cohort study from a Gulf state
OBJECTIVES: A high body mass index (BMI) is associated with risk of type 2 diabetes mellitus (DM). The United Arab Emirates (UAE) is experiencing a marked increase in obesity. Nonetheless, no data are available regarding the incidence of type 2 DM in the high-risk adult UAE population. Therefore, th...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333876/ https://www.ncbi.nlm.nih.gov/pubmed/32616491 http://dx.doi.org/10.1136/bmjopen-2019-035813 |
_version_ | 1783553837079986176 |
---|---|
author | Regmi, Dybesh Al-Shamsi, Saif Govender, Romona D. Al Kaabi, Juma |
author_facet | Regmi, Dybesh Al-Shamsi, Saif Govender, Romona D. Al Kaabi, Juma |
author_sort | Regmi, Dybesh |
collection | PubMed |
description | OBJECTIVES: A high body mass index (BMI) is associated with risk of type 2 diabetes mellitus (DM). The United Arab Emirates (UAE) is experiencing a marked increase in obesity. Nonetheless, no data are available regarding the incidence of type 2 DM in the high-risk adult UAE population. Therefore, this study aimed to evaluate the incidence rate and risk of developing type 2 DM among individuals with above-normal BMI in the UAE. DESIGN: A retrospective cohort study. SETTING: Outpatient clinics at a tertiary care centre in Al Ain, UAE. PARTICIPANTS: Three hundred and sixty-two overweight or obese adult UAE nationals who visited outpatient clinics between April 2008 and December 2008. PRIMARY OUTCOME MEASURE: Patients with type 2 DM were identified based on diagnosis established by a physician or through glycated haemoglobin (HbA1c) levels ≥6.5% during the follow-up period (until April 2018). RESULTS: The overall incidence rate of type 2 DM during the median follow-up time of 8.7 years was 16.3 (95% CI 12.1 to 21.4) cases per 1000 person-years. Incidence rates in men and women were 17.7 (95% CI 11.6 to 25.9) and 15.0 (95% CI 9.8 to 22.2) cases per 1000 person-years, respectively. Multivariable Cox proportional hazard analysis determined older age and obesity in women and pre-diabetes in men to be independent risk factors for developing type 2 DM. CONCLUSIONS: The incidence rate of type 2 DM in overweight and obese UAE nationals is high. In addition to screening, current strategies should strongly emphasise lifestyle modifications to decrease HbA1c and BMI levels in this high-risk population. |
format | Online Article Text |
id | pubmed-7333876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-73338762020-07-07 Incidence and risk factors of type 2 diabetes mellitus in an overweight and obese population: a long-term retrospective cohort study from a Gulf state Regmi, Dybesh Al-Shamsi, Saif Govender, Romona D. Al Kaabi, Juma BMJ Open Diabetes and Endocrinology OBJECTIVES: A high body mass index (BMI) is associated with risk of type 2 diabetes mellitus (DM). The United Arab Emirates (UAE) is experiencing a marked increase in obesity. Nonetheless, no data are available regarding the incidence of type 2 DM in the high-risk adult UAE population. Therefore, this study aimed to evaluate the incidence rate and risk of developing type 2 DM among individuals with above-normal BMI in the UAE. DESIGN: A retrospective cohort study. SETTING: Outpatient clinics at a tertiary care centre in Al Ain, UAE. PARTICIPANTS: Three hundred and sixty-two overweight or obese adult UAE nationals who visited outpatient clinics between April 2008 and December 2008. PRIMARY OUTCOME MEASURE: Patients with type 2 DM were identified based on diagnosis established by a physician or through glycated haemoglobin (HbA1c) levels ≥6.5% during the follow-up period (until April 2018). RESULTS: The overall incidence rate of type 2 DM during the median follow-up time of 8.7 years was 16.3 (95% CI 12.1 to 21.4) cases per 1000 person-years. Incidence rates in men and women were 17.7 (95% CI 11.6 to 25.9) and 15.0 (95% CI 9.8 to 22.2) cases per 1000 person-years, respectively. Multivariable Cox proportional hazard analysis determined older age and obesity in women and pre-diabetes in men to be independent risk factors for developing type 2 DM. CONCLUSIONS: The incidence rate of type 2 DM in overweight and obese UAE nationals is high. In addition to screening, current strategies should strongly emphasise lifestyle modifications to decrease HbA1c and BMI levels in this high-risk population. BMJ Publishing Group 2020-07-02 /pmc/articles/PMC7333876/ /pubmed/32616491 http://dx.doi.org/10.1136/bmjopen-2019-035813 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Diabetes and Endocrinology Regmi, Dybesh Al-Shamsi, Saif Govender, Romona D. Al Kaabi, Juma Incidence and risk factors of type 2 diabetes mellitus in an overweight and obese population: a long-term retrospective cohort study from a Gulf state |
title | Incidence and risk factors of type 2 diabetes mellitus in an overweight and obese population: a long-term retrospective cohort study from a Gulf state |
title_full | Incidence and risk factors of type 2 diabetes mellitus in an overweight and obese population: a long-term retrospective cohort study from a Gulf state |
title_fullStr | Incidence and risk factors of type 2 diabetes mellitus in an overweight and obese population: a long-term retrospective cohort study from a Gulf state |
title_full_unstemmed | Incidence and risk factors of type 2 diabetes mellitus in an overweight and obese population: a long-term retrospective cohort study from a Gulf state |
title_short | Incidence and risk factors of type 2 diabetes mellitus in an overweight and obese population: a long-term retrospective cohort study from a Gulf state |
title_sort | incidence and risk factors of type 2 diabetes mellitus in an overweight and obese population: a long-term retrospective cohort study from a gulf state |
topic | Diabetes and Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333876/ https://www.ncbi.nlm.nih.gov/pubmed/32616491 http://dx.doi.org/10.1136/bmjopen-2019-035813 |
work_keys_str_mv | AT regmidybesh incidenceandriskfactorsoftype2diabetesmellitusinanoverweightandobesepopulationalongtermretrospectivecohortstudyfromagulfstate AT alshamsisaif incidenceandriskfactorsoftype2diabetesmellitusinanoverweightandobesepopulationalongtermretrospectivecohortstudyfromagulfstate AT govenderromonad incidenceandriskfactorsoftype2diabetesmellitusinanoverweightandobesepopulationalongtermretrospectivecohortstudyfromagulfstate AT alkaabijuma incidenceandriskfactorsoftype2diabetesmellitusinanoverweightandobesepopulationalongtermretrospectivecohortstudyfromagulfstate |