Influence of microbiota on immunity and immunotherapy for gastric and esophageal cancers

Gastric and esophageal cancers are multifactorial and multistage-involved malignancy. While the impact of gut microbiota on overall human health and diseases has been well documented, the influence of gastric and esophageal microbiota on gastric and esophageal cancers remains unclear. This review wi...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaoli, Pan, Zui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333930/
https://www.ncbi.nlm.nih.gov/pubmed/32665852
http://dx.doi.org/10.1093/gastro/goaa014
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author Zhang, Xiaoli
Pan, Zui
author_facet Zhang, Xiaoli
Pan, Zui
author_sort Zhang, Xiaoli
collection PubMed
description Gastric and esophageal cancers are multifactorial and multistage-involved malignancy. While the impact of gut microbiota on overall human health and diseases has been well documented, the influence of gastric and esophageal microbiota on gastric and esophageal cancers remains unclear. This review will discuss the reported alteration in the composition of gastric and esophageal microbiota in normal and disease conditions, and the potential role of dysbiosis in carcinogenesis and tumorigenesis. This review will also discuss how dysbiosis stimulates local and systemic immunity, which may impact on the immunotherapy for cancer.
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spelling pubmed-73339302020-07-13 Influence of microbiota on immunity and immunotherapy for gastric and esophageal cancers Zhang, Xiaoli Pan, Zui Gastroenterol Rep (Oxf) Review Articles Gastric and esophageal cancers are multifactorial and multistage-involved malignancy. While the impact of gut microbiota on overall human health and diseases has been well documented, the influence of gastric and esophageal microbiota on gastric and esophageal cancers remains unclear. This review will discuss the reported alteration in the composition of gastric and esophageal microbiota in normal and disease conditions, and the potential role of dysbiosis in carcinogenesis and tumorigenesis. This review will also discuss how dysbiosis stimulates local and systemic immunity, which may impact on the immunotherapy for cancer. Oxford University Press 2020-06-04 /pmc/articles/PMC7333930/ /pubmed/32665852 http://dx.doi.org/10.1093/gastro/goaa014 Text en © The Author(s) 2020. Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-sen University http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Zhang, Xiaoli
Pan, Zui
Influence of microbiota on immunity and immunotherapy for gastric and esophageal cancers
title Influence of microbiota on immunity and immunotherapy for gastric and esophageal cancers
title_full Influence of microbiota on immunity and immunotherapy for gastric and esophageal cancers
title_fullStr Influence of microbiota on immunity and immunotherapy for gastric and esophageal cancers
title_full_unstemmed Influence of microbiota on immunity and immunotherapy for gastric and esophageal cancers
title_short Influence of microbiota on immunity and immunotherapy for gastric and esophageal cancers
title_sort influence of microbiota on immunity and immunotherapy for gastric and esophageal cancers
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333930/
https://www.ncbi.nlm.nih.gov/pubmed/32665852
http://dx.doi.org/10.1093/gastro/goaa014
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