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Tuning of feedforward control enables stable muscle force-length dynamics after loss of autogenic proprioceptive feedback

Animals must integrate feedforward, feedback and intrinsic mechanical control mechanisms to maintain stable locomotion. Recent studies of guinea fowl (Numida meleagris) revealed that the distal leg muscles rapidly modulate force and work output to minimize perturbations in uneven terrain. Here we pr...

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Detalles Bibliográficos
Autores principales: Gordon, Joanne C, Holt, Natalie C, Biewener, Andrew, Daley, Monica A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334023/
https://www.ncbi.nlm.nih.gov/pubmed/32573432
http://dx.doi.org/10.7554/eLife.53908
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author Gordon, Joanne C
Holt, Natalie C
Biewener, Andrew
Daley, Monica A
author_facet Gordon, Joanne C
Holt, Natalie C
Biewener, Andrew
Daley, Monica A
author_sort Gordon, Joanne C
collection PubMed
description Animals must integrate feedforward, feedback and intrinsic mechanical control mechanisms to maintain stable locomotion. Recent studies of guinea fowl (Numida meleagris) revealed that the distal leg muscles rapidly modulate force and work output to minimize perturbations in uneven terrain. Here we probe the role of reflexes in the rapid perturbation responses of muscle by studying the effects of proprioceptive loss. We induced bilateral loss of autogenic proprioception in the lateral gastrocnemius muscle (LG) using self-reinnervation. We compared in vivo muscle dynamics and ankle kinematics in birds with reinnervated and intact LG. Reinnervated and intact LG exhibit similar steady state mechanical function and similar work modulation in response to obstacle encounters. Reinnervated LG exhibits 23ms earlier steady-state activation, consistent with feedforward tuning of activation phase to compensate for lost proprioception. Modulation of activity duration is impaired in rLG, confirming the role of reflex feedback in regulating force duration in intact muscle.
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spelling pubmed-73340232020-07-13 Tuning of feedforward control enables stable muscle force-length dynamics after loss of autogenic proprioceptive feedback Gordon, Joanne C Holt, Natalie C Biewener, Andrew Daley, Monica A eLife Neuroscience Animals must integrate feedforward, feedback and intrinsic mechanical control mechanisms to maintain stable locomotion. Recent studies of guinea fowl (Numida meleagris) revealed that the distal leg muscles rapidly modulate force and work output to minimize perturbations in uneven terrain. Here we probe the role of reflexes in the rapid perturbation responses of muscle by studying the effects of proprioceptive loss. We induced bilateral loss of autogenic proprioception in the lateral gastrocnemius muscle (LG) using self-reinnervation. We compared in vivo muscle dynamics and ankle kinematics in birds with reinnervated and intact LG. Reinnervated and intact LG exhibit similar steady state mechanical function and similar work modulation in response to obstacle encounters. Reinnervated LG exhibits 23ms earlier steady-state activation, consistent with feedforward tuning of activation phase to compensate for lost proprioception. Modulation of activity duration is impaired in rLG, confirming the role of reflex feedback in regulating force duration in intact muscle. eLife Sciences Publications, Ltd 2020-06-23 /pmc/articles/PMC7334023/ /pubmed/32573432 http://dx.doi.org/10.7554/eLife.53908 Text en © 2020, Gordon et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Gordon, Joanne C
Holt, Natalie C
Biewener, Andrew
Daley, Monica A
Tuning of feedforward control enables stable muscle force-length dynamics after loss of autogenic proprioceptive feedback
title Tuning of feedforward control enables stable muscle force-length dynamics after loss of autogenic proprioceptive feedback
title_full Tuning of feedforward control enables stable muscle force-length dynamics after loss of autogenic proprioceptive feedback
title_fullStr Tuning of feedforward control enables stable muscle force-length dynamics after loss of autogenic proprioceptive feedback
title_full_unstemmed Tuning of feedforward control enables stable muscle force-length dynamics after loss of autogenic proprioceptive feedback
title_short Tuning of feedforward control enables stable muscle force-length dynamics after loss of autogenic proprioceptive feedback
title_sort tuning of feedforward control enables stable muscle force-length dynamics after loss of autogenic proprioceptive feedback
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334023/
https://www.ncbi.nlm.nih.gov/pubmed/32573432
http://dx.doi.org/10.7554/eLife.53908
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