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The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways

The expanded polyglutamine (polyQ) tract form of ataxin-1 drives disease progression in spinocerebellar ataxia type 1 (SCA1). Although known to form distinctive intranuclear bodies, the cellular pathways and processes that polyQ-ataxin-1 influences remain poorly understood. Here we identify the dire...

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Detalles Bibliográficos
Autores principales:	Zhang, Sunyuan, Williamson, Nicholas A., Duvick, Lisa, Lee, Alexander, Orr, Harry T., Korlin-Downs, Austin, Yang, Praseuth, Mok, Yee-Foong, Jans, David A., Bogoyevitch, Marie A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334205/ https://www.ncbi.nlm.nih.gov/pubmed/32620905 http://dx.doi.org/10.1038/s41467-020-17145-0

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