Comparison of (68)Ga-PSMA-617 PET/CT with mpMRI for the detection of PCa in patients with a PSA level of 4–20 ng/ml before the initial biopsy

The study was aimed at assessing the diagnostic performance of (68)Ga-PSMA-617 PET/CT in the detection of prostate cancer (PCa) in patients with a prostate-specific antigen (PSA) level of 4–20 ng/ml and to compare its efficacy with that of multiparametric MRI (mpMRI). We analyzed the data of 67 cons...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yu, Han, Donghui, Wu, Peng, Ren, Jing, Ma, Shuaijun, Zhang, Jingliang, Song, Wei, Lin, Xiaoyu, Jiao, Dian, Shi, Shengjia, Yang, Fa, Wu, Jieheng, Meng, Ping, Wen, Weihong, Kang, Fei, Wang, Jing, Qin, Weijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334214/
https://www.ncbi.nlm.nih.gov/pubmed/32620790
http://dx.doi.org/10.1038/s41598-020-67385-9
_version_ 1783553891956162560
author Li, Yu
Han, Donghui
Wu, Peng
Ren, Jing
Ma, Shuaijun
Zhang, Jingliang
Song, Wei
Lin, Xiaoyu
Jiao, Dian
Shi, Shengjia
Yang, Fa
Wu, Jieheng
Meng, Ping
Wen, Weihong
Kang, Fei
Wang, Jing
Qin, Weijun
author_facet Li, Yu
Han, Donghui
Wu, Peng
Ren, Jing
Ma, Shuaijun
Zhang, Jingliang
Song, Wei
Lin, Xiaoyu
Jiao, Dian
Shi, Shengjia
Yang, Fa
Wu, Jieheng
Meng, Ping
Wen, Weihong
Kang, Fei
Wang, Jing
Qin, Weijun
author_sort Li, Yu
collection PubMed
description The study was aimed at assessing the diagnostic performance of (68)Ga-PSMA-617 PET/CT in the detection of prostate cancer (PCa) in patients with a prostate-specific antigen (PSA) level of 4–20 ng/ml and to compare its efficacy with that of multiparametric MRI (mpMRI). We analyzed the data of 67 consecutive patients with PSA levels of 4–20 ng/ml who almost simultaneously underwent (68)Ga-PSMA-617 PET/CT and mpMRI. (68)Ga-PSMA-617 PET/CT and mpMRI diagnostic performances were compared via receiver operating characteristic (ROC) curve analysis. Of the 67 suspected PCa cases, 33 had pathologically confirmed PCa. (68)Ga-PSMA-617 PET/CT showed a patient-based sensitivity, specificity, and positive and negative predictive values (PPVs and NPVs) of 87.88%, 88.24%, 87.88%, and 88.24%, respectively. The corresponding values for mpMRI were 84.85%, 52.94%, 63.64%, and 78.26%. The area under the curve values for (68)Ga-PSMA-617 PET/CT and mpMRI were 0.881 and 0.689, respectively. (68)Ga-PSMA-617 PET/CT showed a better diagnostic performance than mpMRI in the detection of PCa in patients with PSA levels of 4–20 ng/ml.
format Online
Article
Text
id pubmed-7334214
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-73342142020-07-07 Comparison of (68)Ga-PSMA-617 PET/CT with mpMRI for the detection of PCa in patients with a PSA level of 4–20 ng/ml before the initial biopsy Li, Yu Han, Donghui Wu, Peng Ren, Jing Ma, Shuaijun Zhang, Jingliang Song, Wei Lin, Xiaoyu Jiao, Dian Shi, Shengjia Yang, Fa Wu, Jieheng Meng, Ping Wen, Weihong Kang, Fei Wang, Jing Qin, Weijun Sci Rep Article The study was aimed at assessing the diagnostic performance of (68)Ga-PSMA-617 PET/CT in the detection of prostate cancer (PCa) in patients with a prostate-specific antigen (PSA) level of 4–20 ng/ml and to compare its efficacy with that of multiparametric MRI (mpMRI). We analyzed the data of 67 consecutive patients with PSA levels of 4–20 ng/ml who almost simultaneously underwent (68)Ga-PSMA-617 PET/CT and mpMRI. (68)Ga-PSMA-617 PET/CT and mpMRI diagnostic performances were compared via receiver operating characteristic (ROC) curve analysis. Of the 67 suspected PCa cases, 33 had pathologically confirmed PCa. (68)Ga-PSMA-617 PET/CT showed a patient-based sensitivity, specificity, and positive and negative predictive values (PPVs and NPVs) of 87.88%, 88.24%, 87.88%, and 88.24%, respectively. The corresponding values for mpMRI were 84.85%, 52.94%, 63.64%, and 78.26%. The area under the curve values for (68)Ga-PSMA-617 PET/CT and mpMRI were 0.881 and 0.689, respectively. (68)Ga-PSMA-617 PET/CT showed a better diagnostic performance than mpMRI in the detection of PCa in patients with PSA levels of 4–20 ng/ml. Nature Publishing Group UK 2020-07-03 /pmc/articles/PMC7334214/ /pubmed/32620790 http://dx.doi.org/10.1038/s41598-020-67385-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Li, Yu
Han, Donghui
Wu, Peng
Ren, Jing
Ma, Shuaijun
Zhang, Jingliang
Song, Wei
Lin, Xiaoyu
Jiao, Dian
Shi, Shengjia
Yang, Fa
Wu, Jieheng
Meng, Ping
Wen, Weihong
Kang, Fei
Wang, Jing
Qin, Weijun
Comparison of (68)Ga-PSMA-617 PET/CT with mpMRI for the detection of PCa in patients with a PSA level of 4–20 ng/ml before the initial biopsy
title Comparison of (68)Ga-PSMA-617 PET/CT with mpMRI for the detection of PCa in patients with a PSA level of 4–20 ng/ml before the initial biopsy
title_full Comparison of (68)Ga-PSMA-617 PET/CT with mpMRI for the detection of PCa in patients with a PSA level of 4–20 ng/ml before the initial biopsy
title_fullStr Comparison of (68)Ga-PSMA-617 PET/CT with mpMRI for the detection of PCa in patients with a PSA level of 4–20 ng/ml before the initial biopsy
title_full_unstemmed Comparison of (68)Ga-PSMA-617 PET/CT with mpMRI for the detection of PCa in patients with a PSA level of 4–20 ng/ml before the initial biopsy
title_short Comparison of (68)Ga-PSMA-617 PET/CT with mpMRI for the detection of PCa in patients with a PSA level of 4–20 ng/ml before the initial biopsy
title_sort comparison of (68)ga-psma-617 pet/ct with mpmri for the detection of pca in patients with a psa level of 4–20 ng/ml before the initial biopsy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334214/
https://www.ncbi.nlm.nih.gov/pubmed/32620790
http://dx.doi.org/10.1038/s41598-020-67385-9
work_keys_str_mv AT liyu comparisonof68gapsma617petctwithmpmriforthedetectionofpcainpatientswithapsalevelof420ngmlbeforetheinitialbiopsy
AT handonghui comparisonof68gapsma617petctwithmpmriforthedetectionofpcainpatientswithapsalevelof420ngmlbeforetheinitialbiopsy
AT wupeng comparisonof68gapsma617petctwithmpmriforthedetectionofpcainpatientswithapsalevelof420ngmlbeforetheinitialbiopsy
AT renjing comparisonof68gapsma617petctwithmpmriforthedetectionofpcainpatientswithapsalevelof420ngmlbeforetheinitialbiopsy
AT mashuaijun comparisonof68gapsma617petctwithmpmriforthedetectionofpcainpatientswithapsalevelof420ngmlbeforetheinitialbiopsy
AT zhangjingliang comparisonof68gapsma617petctwithmpmriforthedetectionofpcainpatientswithapsalevelof420ngmlbeforetheinitialbiopsy
AT songwei comparisonof68gapsma617petctwithmpmriforthedetectionofpcainpatientswithapsalevelof420ngmlbeforetheinitialbiopsy
AT linxiaoyu comparisonof68gapsma617petctwithmpmriforthedetectionofpcainpatientswithapsalevelof420ngmlbeforetheinitialbiopsy
AT jiaodian comparisonof68gapsma617petctwithmpmriforthedetectionofpcainpatientswithapsalevelof420ngmlbeforetheinitialbiopsy
AT shishengjia comparisonof68gapsma617petctwithmpmriforthedetectionofpcainpatientswithapsalevelof420ngmlbeforetheinitialbiopsy
AT yangfa comparisonof68gapsma617petctwithmpmriforthedetectionofpcainpatientswithapsalevelof420ngmlbeforetheinitialbiopsy
AT wujieheng comparisonof68gapsma617petctwithmpmriforthedetectionofpcainpatientswithapsalevelof420ngmlbeforetheinitialbiopsy
AT mengping comparisonof68gapsma617petctwithmpmriforthedetectionofpcainpatientswithapsalevelof420ngmlbeforetheinitialbiopsy
AT wenweihong comparisonof68gapsma617petctwithmpmriforthedetectionofpcainpatientswithapsalevelof420ngmlbeforetheinitialbiopsy
AT kangfei comparisonof68gapsma617petctwithmpmriforthedetectionofpcainpatientswithapsalevelof420ngmlbeforetheinitialbiopsy
AT wangjing comparisonof68gapsma617petctwithmpmriforthedetectionofpcainpatientswithapsalevelof420ngmlbeforetheinitialbiopsy
AT qinweijun comparisonof68gapsma617petctwithmpmriforthedetectionofpcainpatientswithapsalevelof420ngmlbeforetheinitialbiopsy

Ejemplares similares