NCLX prevents cell death during adrenergic activation of the brown adipose tissue

A sharp increase in mitochondrial Ca(2+) marks the activation of brown adipose tissue (BAT) thermogenesis, yet the mechanisms preventing Ca(2+) deleterious effects are poorly understood. Here, we show that adrenergic stimulation of BAT activates a PKA-dependent mitochondrial Ca(2+) extrusion via the...

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Detalles Bibliográficos
Autores principales: Assali, Essam A., Jones, Anthony E., Veliova, Michaela, Acín-Pérez, Rebeca, Taha, Mahmoud, Miller, Nathanael, Shum, Michaël, Oliveira, Marcus F., Las, Guy, Liesa, Marc, Sekler, Israel, Shirihai, Orian S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334226/
https://www.ncbi.nlm.nih.gov/pubmed/32620768
http://dx.doi.org/10.1038/s41467-020-16572-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334226/
https://www.ncbi.nlm.nih.gov/pubmed/32620768
http://dx.doi.org/10.1038/s41467-020-16572-3

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