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Antithrombin III treatment for portal vein thrombosis after living donor liver transplantation: a case report

BACKGROUND: There have been no reports on the effectiveness of the administration of antithrombin III (AT III) for post-transplant portal vein thrombosis (PVT). We herein report a case of post-transplant PVT that was resolved by AT III treatment after living donor liver transplantation (LDLT). CASE...

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Autores principales: Hirata, Yuta, Sanada, Yukihiro, Omameuda, Takahiko, Katano, Takumi, Miyahara, Go, Yamada, Naoya, Okada, Noriki, Onishi, Yasuharu, Sakuma, Yasunaru, Sata, Naohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334317/
https://www.ncbi.nlm.nih.gov/pubmed/32621097
http://dx.doi.org/10.1186/s40792-020-00920-y
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author Hirata, Yuta
Sanada, Yukihiro
Omameuda, Takahiko
Katano, Takumi
Miyahara, Go
Yamada, Naoya
Okada, Noriki
Onishi, Yasuharu
Sakuma, Yasunaru
Sata, Naohiro
author_facet Hirata, Yuta
Sanada, Yukihiro
Omameuda, Takahiko
Katano, Takumi
Miyahara, Go
Yamada, Naoya
Okada, Noriki
Onishi, Yasuharu
Sakuma, Yasunaru
Sata, Naohiro
author_sort Hirata, Yuta
collection PubMed
description BACKGROUND: There have been no reports on the effectiveness of the administration of antithrombin III (AT III) for post-transplant portal vein thrombosis (PVT). We herein report a case of post-transplant PVT that was resolved by AT III treatment after living donor liver transplantation (LDLT). CASE PRESENTATION: The patient was a 57-year-old man who had been diagnosed with decompensate liver cirrhosis by hepatitis C virus infection. He presented with repeated hepatic coma and refractory ascites. Computed tomography (CT) revealed PVT of Yerdel classification grade II before LDLT. He underwent ABO-identical LDLT using a right lobe graft. A liver function test revealed elevated liver enzyme levels on post-operative day (POD) 14. The CT examination on POD 15 revealed PVT in the left side of the main portal vein at the side of left gastric vein ligation. AT III treatment from POD 15 to POD 24 was performed. Magnetic resonance imaging revealed that the PVT had decreased 10% on POD 27. Furthermore, AT III treatment from POD 28 to POD 32 was performed. The CT examination demonstrated the disappearance of PVT on POD 69 and thereafter, he had no recurrence of PVT on 10 post-operative month (POM). CONCLUSIONS: The present case suggests that the administration of AT III is safe and suitable for the treatment of post-transplant PVT.
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spelling pubmed-73343172020-07-09 Antithrombin III treatment for portal vein thrombosis after living donor liver transplantation: a case report Hirata, Yuta Sanada, Yukihiro Omameuda, Takahiko Katano, Takumi Miyahara, Go Yamada, Naoya Okada, Noriki Onishi, Yasuharu Sakuma, Yasunaru Sata, Naohiro Surg Case Rep Case Report BACKGROUND: There have been no reports on the effectiveness of the administration of antithrombin III (AT III) for post-transplant portal vein thrombosis (PVT). We herein report a case of post-transplant PVT that was resolved by AT III treatment after living donor liver transplantation (LDLT). CASE PRESENTATION: The patient was a 57-year-old man who had been diagnosed with decompensate liver cirrhosis by hepatitis C virus infection. He presented with repeated hepatic coma and refractory ascites. Computed tomography (CT) revealed PVT of Yerdel classification grade II before LDLT. He underwent ABO-identical LDLT using a right lobe graft. A liver function test revealed elevated liver enzyme levels on post-operative day (POD) 14. The CT examination on POD 15 revealed PVT in the left side of the main portal vein at the side of left gastric vein ligation. AT III treatment from POD 15 to POD 24 was performed. Magnetic resonance imaging revealed that the PVT had decreased 10% on POD 27. Furthermore, AT III treatment from POD 28 to POD 32 was performed. The CT examination demonstrated the disappearance of PVT on POD 69 and thereafter, he had no recurrence of PVT on 10 post-operative month (POM). CONCLUSIONS: The present case suggests that the administration of AT III is safe and suitable for the treatment of post-transplant PVT. Springer Berlin Heidelberg 2020-07-03 /pmc/articles/PMC7334317/ /pubmed/32621097 http://dx.doi.org/10.1186/s40792-020-00920-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Case Report
Hirata, Yuta
Sanada, Yukihiro
Omameuda, Takahiko
Katano, Takumi
Miyahara, Go
Yamada, Naoya
Okada, Noriki
Onishi, Yasuharu
Sakuma, Yasunaru
Sata, Naohiro
Antithrombin III treatment for portal vein thrombosis after living donor liver transplantation: a case report
title Antithrombin III treatment for portal vein thrombosis after living donor liver transplantation: a case report
title_full Antithrombin III treatment for portal vein thrombosis after living donor liver transplantation: a case report
title_fullStr Antithrombin III treatment for portal vein thrombosis after living donor liver transplantation: a case report
title_full_unstemmed Antithrombin III treatment for portal vein thrombosis after living donor liver transplantation: a case report
title_short Antithrombin III treatment for portal vein thrombosis after living donor liver transplantation: a case report
title_sort antithrombin iii treatment for portal vein thrombosis after living donor liver transplantation: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334317/
https://www.ncbi.nlm.nih.gov/pubmed/32621097
http://dx.doi.org/10.1186/s40792-020-00920-y
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