Loss of ZIP facilitates JAK2-STAT3 activation in tamoxifen-resistant breast cancer

Tamoxifen, a widely used modulator of the estrogen receptor (ER), targets ER-positive breast cancer preferentially. We used a powerful validation-based insertion mutagenesis method to find that expression of a dominant-negative, truncated form of the histone deacetylase ZIP led to resistance to tamo...

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Detalles Bibliográficos
Autores principales: Zhu, Ning, Zhang, Jing, Du, Yuping, Qin, Xiaodong, Miao, Ruidong, Nan, Jing, Chen, Xing, Sun, Jingjie, Zhao, Rui, Zhang, Xinxin, Shi, Lei, Li, Xin, Lin, Yuxi, Wei, Wei, Mao, Aihong, Zhang, Zhao, Stark, George R., Wang, Yuxin, Yang, Jinbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334450/
https://www.ncbi.nlm.nih.gov/pubmed/32532922
http://dx.doi.org/10.1073/pnas.1910278117

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