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Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD
Preclinical assessment of the therapeutic potential of dopamine (DA) neuron replacement in Parkinson’s disease (PD) has primarily been performed in the 6-hydroxydopamine toxin model. While this is a good model to assess graft function, it does not reflect the pathological features or progressive nat...
Autores principales: | Hoban, Deirdre B., Shrigley, Shelby, Mattsson, Bengt, Breger, Ludivine S., Jarl, Ulla, Cardoso, Tiago, Nelander Wahlestedt, Jenny, Luk, Kelvin C., Björklund, Anders, Parmar, Malin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334514/ https://www.ncbi.nlm.nih.gov/pubmed/32541058 http://dx.doi.org/10.1073/pnas.2001305117 |
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