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Visualizing Human Colorectal Cancer Intratumor Heterogeneity with Phylogeography
Phylogeography combines ancestry with location and can be translated to intratumor heterogeneity (ITH) to visualize how tumors spread. ITH is common in human tumors, with many genetic and phenotypic differences between regions. The roles of ITH in progression are uncertain because many subclones lac...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Elsevier
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334596/ https://www.ncbi.nlm.nih.gov/pubmed/32623333 http://dx.doi.org/10.1016/j.isci.2020.101304 |
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author | Shibata, Darryl |
author_facet | Shibata, Darryl |
author_sort | Shibata, Darryl |
collection | PubMed |
description | Phylogeography combines ancestry with location and can be translated to intratumor heterogeneity (ITH) to visualize how tumors spread. ITH is common in human tumors, with many genetic and phenotypic differences between regions. The roles of ITH in progression are uncertain because many subclones lack discernable driver mutations. ITH can be visualized by mapping mutations onto microscopic sections, where subclones are directly associated with phenotypes, especially the deeper areas with the more invasive cells that confer worst clinical outcomes. Instead of a stepwise hierarchy where subclones segregate by phenotype with later branching subclones in more invasive areas, multiple subclones share superficial and invasive phenotype and are jigsaw arrayed in vertical columns. Phylogeography shows that both early and late subclones extend from the surface to the invasive front, suggesting that founder cells start with phenotypic plasticity and essentially all the drivers necessary to rapidly grow into large invasive tumors. |
format | Online Article Text |
id | pubmed-7334596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-73345962020-07-07 Visualizing Human Colorectal Cancer Intratumor Heterogeneity with Phylogeography Shibata, Darryl iScience Review Phylogeography combines ancestry with location and can be translated to intratumor heterogeneity (ITH) to visualize how tumors spread. ITH is common in human tumors, with many genetic and phenotypic differences between regions. The roles of ITH in progression are uncertain because many subclones lack discernable driver mutations. ITH can be visualized by mapping mutations onto microscopic sections, where subclones are directly associated with phenotypes, especially the deeper areas with the more invasive cells that confer worst clinical outcomes. Instead of a stepwise hierarchy where subclones segregate by phenotype with later branching subclones in more invasive areas, multiple subclones share superficial and invasive phenotype and are jigsaw arrayed in vertical columns. Phylogeography shows that both early and late subclones extend from the surface to the invasive front, suggesting that founder cells start with phenotypic plasticity and essentially all the drivers necessary to rapidly grow into large invasive tumors. Elsevier 2020-06-23 /pmc/articles/PMC7334596/ /pubmed/32623333 http://dx.doi.org/10.1016/j.isci.2020.101304 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Shibata, Darryl Visualizing Human Colorectal Cancer Intratumor Heterogeneity with Phylogeography |
title | Visualizing Human Colorectal Cancer Intratumor Heterogeneity with Phylogeography |
title_full | Visualizing Human Colorectal Cancer Intratumor Heterogeneity with Phylogeography |
title_fullStr | Visualizing Human Colorectal Cancer Intratumor Heterogeneity with Phylogeography |
title_full_unstemmed | Visualizing Human Colorectal Cancer Intratumor Heterogeneity with Phylogeography |
title_short | Visualizing Human Colorectal Cancer Intratumor Heterogeneity with Phylogeography |
title_sort | visualizing human colorectal cancer intratumor heterogeneity with phylogeography |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334596/ https://www.ncbi.nlm.nih.gov/pubmed/32623333 http://dx.doi.org/10.1016/j.isci.2020.101304 |
work_keys_str_mv | AT shibatadarryl visualizinghumancolorectalcancerintratumorheterogeneitywithphylogeography |