A conformation-specific ON-switch for controlling CAR T cells with an orally available drug

Molecular ON-switches in which a chemical compound induces protein–protein interactions can allow cellular function to be controlled with small molecules. ON-switches based on clinically applicable compounds and human proteins would greatly facilitate their therapeutic use. Here, we developed an ON-...

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Detalles Bibliográficos
Autores principales: Zajc, Charlotte U., Dobersberger, Markus, Schaffner, Irene, Mlynek, Georg, Pühringer, Dominic, Salzer, Benjamin, Djinović-Carugo, Kristina, Steinberger, Peter, De Sousa Linhares, Annika, Yang, Nicole J., Obinger, Christian, Holter, Wolfgang, Traxlmayr, Michael W., Lehner, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334647/
https://www.ncbi.nlm.nih.gov/pubmed/32554495
http://dx.doi.org/10.1073/pnas.1911154117

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