AIMTOR, a BRET biosensor for live imaging, reveals subcellular mTOR signaling and dysfunctions

BACKGROUND: mTOR signaling is an essential nutrient and energetic sensing pathway. Here we describe AIMTOR, a sensitive genetically encoded BRET (Bioluminescent Resonance Energy Transfer) biosensor to study mTOR activity in living cells. RESULTS: As a proof of principle, we show in both cell lines a...

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Detalles Bibliográficos
Autores principales: Bouquier, Nathalie, Moutin, Enora, Tintignac, Lionel A., Reverbel, Amandine, Jublanc, Elodie, Sinnreich, Michael, Chastagnier, Yan, Averous, Julien, Fafournoux, Pierre, Verpelli, Chiara, Boeckers, Tobias, Carnac, Gilles, Perroy, Julie, Ollendorff, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334845/
https://www.ncbi.nlm.nih.gov/pubmed/32620110
http://dx.doi.org/10.1186/s12915-020-00790-8

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