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Screening of vitamin D and calcium concentrations in neonates of mothers at high risk of vitamin D deficiency
OBJECTIVE: The aim of this study was to determine, retrospectively, the serum 25OHD and calcium concentrations of screened neonates of mothers at high risk of 25OHD deficiency and examine whether their measurement contributes to the management of these neonates. METHODS: Serum 25OHD and calcium conc...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334853/ https://www.ncbi.nlm.nih.gov/pubmed/32620093 http://dx.doi.org/10.1186/s12887-020-02204-8 |
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author | Kozgar, Sheikh Arif M. Chay, Paul Munns, Craig F. |
author_facet | Kozgar, Sheikh Arif M. Chay, Paul Munns, Craig F. |
author_sort | Kozgar, Sheikh Arif M. |
collection | PubMed |
description | OBJECTIVE: The aim of this study was to determine, retrospectively, the serum 25OHD and calcium concentrations of screened neonates of mothers at high risk of 25OHD deficiency and examine whether their measurement contributes to the management of these neonates. METHODS: Serum 25OHD and calcium concentrations from 600 samples of umbilical cord blood or venous blood collected from neonates over a 12-month period were analysed. RESULTS: There was a high prevalence of vitamin D insufficiency (27.6%, 30–50 nmol/L) and deficiency (21.3%, < 30 nmol/L) in neonates from high-risk maternal groups. There was a statistically positive but weak correlation (ρ = 0.22, P < 0.0001) between 25OHD and serum calcium. Only 7 neonates out of 569 (1.2%) had calcium concentrations in the hypocalcaemic range; however, a significant number (47.6%) were reported to be in the hypercalcaemic range. Nearly all of these were venous samples collected in first 24 h after birth. CONCLUSION: Vitamin D deficiency is prevalent in neonates of high-risk mothers but the risk of hypocalcaemia due to vitamin D deficiency at birth is low. Screening neonates entails blood testing which can cause distress to neonates and their parents, substantial imposition on staff and financial burden on the health care system. Vitamin D supplementation of these neonates from birth without routine screening appears more reasonable. Also, the data from this study suggest that the paediatric reference range for corrected calcium concentrations in neonates should be re-evaluated. |
format | Online Article Text |
id | pubmed-7334853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-73348532020-07-06 Screening of vitamin D and calcium concentrations in neonates of mothers at high risk of vitamin D deficiency Kozgar, Sheikh Arif M. Chay, Paul Munns, Craig F. BMC Pediatr Research Article OBJECTIVE: The aim of this study was to determine, retrospectively, the serum 25OHD and calcium concentrations of screened neonates of mothers at high risk of 25OHD deficiency and examine whether their measurement contributes to the management of these neonates. METHODS: Serum 25OHD and calcium concentrations from 600 samples of umbilical cord blood or venous blood collected from neonates over a 12-month period were analysed. RESULTS: There was a high prevalence of vitamin D insufficiency (27.6%, 30–50 nmol/L) and deficiency (21.3%, < 30 nmol/L) in neonates from high-risk maternal groups. There was a statistically positive but weak correlation (ρ = 0.22, P < 0.0001) between 25OHD and serum calcium. Only 7 neonates out of 569 (1.2%) had calcium concentrations in the hypocalcaemic range; however, a significant number (47.6%) were reported to be in the hypercalcaemic range. Nearly all of these were venous samples collected in first 24 h after birth. CONCLUSION: Vitamin D deficiency is prevalent in neonates of high-risk mothers but the risk of hypocalcaemia due to vitamin D deficiency at birth is low. Screening neonates entails blood testing which can cause distress to neonates and their parents, substantial imposition on staff and financial burden on the health care system. Vitamin D supplementation of these neonates from birth without routine screening appears more reasonable. Also, the data from this study suggest that the paediatric reference range for corrected calcium concentrations in neonates should be re-evaluated. BioMed Central 2020-07-04 /pmc/articles/PMC7334853/ /pubmed/32620093 http://dx.doi.org/10.1186/s12887-020-02204-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Kozgar, Sheikh Arif M. Chay, Paul Munns, Craig F. Screening of vitamin D and calcium concentrations in neonates of mothers at high risk of vitamin D deficiency |
title | Screening of vitamin D and calcium concentrations in neonates of mothers at high risk of vitamin D deficiency |
title_full | Screening of vitamin D and calcium concentrations in neonates of mothers at high risk of vitamin D deficiency |
title_fullStr | Screening of vitamin D and calcium concentrations in neonates of mothers at high risk of vitamin D deficiency |
title_full_unstemmed | Screening of vitamin D and calcium concentrations in neonates of mothers at high risk of vitamin D deficiency |
title_short | Screening of vitamin D and calcium concentrations in neonates of mothers at high risk of vitamin D deficiency |
title_sort | screening of vitamin d and calcium concentrations in neonates of mothers at high risk of vitamin d deficiency |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334853/ https://www.ncbi.nlm.nih.gov/pubmed/32620093 http://dx.doi.org/10.1186/s12887-020-02204-8 |
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