TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity

BACKGROUND: Mutations in the small RNA-binding protein TDP-43 lead to the formation of insoluble cytoplasmic aggregates that have been associated with the onset and progression of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder affecting homeostasis of the motor system which is als...

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Detalles Bibliográficos
Autores principales: Romano, Giulia, Klima, Raffaella, Feiguin, Fabian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334854/
https://www.ncbi.nlm.nih.gov/pubmed/32620127
http://dx.doi.org/10.1186/s12915-020-00816-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334854/
https://www.ncbi.nlm.nih.gov/pubmed/32620127
http://dx.doi.org/10.1186/s12915-020-00816-1

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