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TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity
BACKGROUND: Mutations in the small RNA-binding protein TDP-43 lead to the formation of insoluble cytoplasmic aggregates that have been associated with the onset and progression of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder affecting homeostasis of the motor system which is als...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334854/ https://www.ncbi.nlm.nih.gov/pubmed/32620127 http://dx.doi.org/10.1186/s12915-020-00816-1 |