A role for external Ca(2+) in maintaining muscle contractility in periodic paralysis

Calcium gluconate has been empirically administered to hasten recovery of force during an episode of periodic paralysis. By using a genetically engineered mouse model, Uwera and colleagues show that low Ca(2+) clearly promotes a loss of force in affected muscle, thereby providing the first evidence...

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Detalles Bibliográficos
Autor principal: Cannon, Stephen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335007/
https://www.ncbi.nlm.nih.gov/pubmed/32463879
http://dx.doi.org/10.1085/jgp.202012615
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author Cannon, Stephen C.
author_facet Cannon, Stephen C.
author_sort Cannon, Stephen C.
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description Calcium gluconate has been empirically administered to hasten recovery of force during an episode of periodic paralysis. By using a genetically engineered mouse model, Uwera and colleagues show that low Ca(2+) clearly promotes a loss of force in affected muscle, thereby providing the first evidence for the benefit of maintaining normal Ca(2+) levels in this disorder.
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spelling pubmed-73350072021-01-06 A role for external Ca(2+) in maintaining muscle contractility in periodic paralysis Cannon, Stephen C. J Gen Physiol Commentary Calcium gluconate has been empirically administered to hasten recovery of force during an episode of periodic paralysis. By using a genetically engineered mouse model, Uwera and colleagues show that low Ca(2+) clearly promotes a loss of force in affected muscle, thereby providing the first evidence for the benefit of maintaining normal Ca(2+) levels in this disorder. Rockefeller University Press 2020-05-28 /pmc/articles/PMC7335007/ /pubmed/32463879 http://dx.doi.org/10.1085/jgp.202012615 Text en © 2020 Cannon http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Cannon, Stephen C.
A role for external Ca(2+) in maintaining muscle contractility in periodic paralysis
title A role for external Ca(2+) in maintaining muscle contractility in periodic paralysis
title_full A role for external Ca(2+) in maintaining muscle contractility in periodic paralysis
title_fullStr A role for external Ca(2+) in maintaining muscle contractility in periodic paralysis
title_full_unstemmed A role for external Ca(2+) in maintaining muscle contractility in periodic paralysis
title_short A role for external Ca(2+) in maintaining muscle contractility in periodic paralysis
title_sort role for external ca(2+) in maintaining muscle contractility in periodic paralysis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335007/
https://www.ncbi.nlm.nih.gov/pubmed/32463879
http://dx.doi.org/10.1085/jgp.202012615
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