Cargando…

Impact of quantitative pulmonary emphysema score on the rate of pneumothorax and chest tube insertion in CT-guided lung biopsies

The aim of this study was to evaluate the risk of pneumothorax and need for chest tube insertion in CT-guided lung biopsies and identify predictors focusing on pulmonary emphysema determined with quantitative computed tomography. To that end, we retrospectively analysed the incidence of pneumothorax...

Descripción completa

Detalles Bibliográficos
Autores principales: Theilig, Dorothea, Petschelt, David, Mayerhofer, Anna, Hamm, Bernd, Gebauer, Bernhard, Geisel, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335035/
https://www.ncbi.nlm.nih.gov/pubmed/32620852
http://dx.doi.org/10.1038/s41598-020-67348-0
_version_ 1783554054390022144
author Theilig, Dorothea
Petschelt, David
Mayerhofer, Anna
Hamm, Bernd
Gebauer, Bernhard
Geisel, Dominik
author_facet Theilig, Dorothea
Petschelt, David
Mayerhofer, Anna
Hamm, Bernd
Gebauer, Bernhard
Geisel, Dominik
author_sort Theilig, Dorothea
collection PubMed
description The aim of this study was to evaluate the risk of pneumothorax and need for chest tube insertion in CT-guided lung biopsies and identify predictors focusing on pulmonary emphysema determined with quantitative computed tomography. To that end, we retrospectively analysed the incidence of pneumothorax and chest tube insertion in 371 CT-guided lung biopsies with respect to the quantitative emphysema score determined with the density mask technique. Other possible impact factors considered were lesion diameter, length of biopsy pathway within the lung parenchyma, lung lobe, needle size, puncture technique, patient positioning and interventionalist’s level of experience. Quantitative emphysema scores of the lung were significantly higher in patients who developed instant pneumothorax (27%, p < 0.0001), overall pneumothorax (38%, p = 0.001) and had chest tube insertion (9%, p = 0.006) compared to those who did not when analysed with the Mann–Whitney U-test. In logistic regression analysis with inclusion of the other possible impact factors, the quantitative emphysema score remained a statistically significant predictor for all three output parameters. This was confirmed with least absolute shrinkage and selection operator (Lasso) regression analysis. In conclusion, quantitatively determined pulmonary emphysema is a positive predictor of the pneumothorax rate in CT-guided lung biopsy and likelihood of chest tube insertion.
format Online
Article
Text
id pubmed-7335035
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-73350352020-07-07 Impact of quantitative pulmonary emphysema score on the rate of pneumothorax and chest tube insertion in CT-guided lung biopsies Theilig, Dorothea Petschelt, David Mayerhofer, Anna Hamm, Bernd Gebauer, Bernhard Geisel, Dominik Sci Rep Article The aim of this study was to evaluate the risk of pneumothorax and need for chest tube insertion in CT-guided lung biopsies and identify predictors focusing on pulmonary emphysema determined with quantitative computed tomography. To that end, we retrospectively analysed the incidence of pneumothorax and chest tube insertion in 371 CT-guided lung biopsies with respect to the quantitative emphysema score determined with the density mask technique. Other possible impact factors considered were lesion diameter, length of biopsy pathway within the lung parenchyma, lung lobe, needle size, puncture technique, patient positioning and interventionalist’s level of experience. Quantitative emphysema scores of the lung were significantly higher in patients who developed instant pneumothorax (27%, p < 0.0001), overall pneumothorax (38%, p = 0.001) and had chest tube insertion (9%, p = 0.006) compared to those who did not when analysed with the Mann–Whitney U-test. In logistic regression analysis with inclusion of the other possible impact factors, the quantitative emphysema score remained a statistically significant predictor for all three output parameters. This was confirmed with least absolute shrinkage and selection operator (Lasso) regression analysis. In conclusion, quantitatively determined pulmonary emphysema is a positive predictor of the pneumothorax rate in CT-guided lung biopsy and likelihood of chest tube insertion. Nature Publishing Group UK 2020-07-03 /pmc/articles/PMC7335035/ /pubmed/32620852 http://dx.doi.org/10.1038/s41598-020-67348-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Theilig, Dorothea
Petschelt, David
Mayerhofer, Anna
Hamm, Bernd
Gebauer, Bernhard
Geisel, Dominik
Impact of quantitative pulmonary emphysema score on the rate of pneumothorax and chest tube insertion in CT-guided lung biopsies
title Impact of quantitative pulmonary emphysema score on the rate of pneumothorax and chest tube insertion in CT-guided lung biopsies
title_full Impact of quantitative pulmonary emphysema score on the rate of pneumothorax and chest tube insertion in CT-guided lung biopsies
title_fullStr Impact of quantitative pulmonary emphysema score on the rate of pneumothorax and chest tube insertion in CT-guided lung biopsies
title_full_unstemmed Impact of quantitative pulmonary emphysema score on the rate of pneumothorax and chest tube insertion in CT-guided lung biopsies
title_short Impact of quantitative pulmonary emphysema score on the rate of pneumothorax and chest tube insertion in CT-guided lung biopsies
title_sort impact of quantitative pulmonary emphysema score on the rate of pneumothorax and chest tube insertion in ct-guided lung biopsies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335035/
https://www.ncbi.nlm.nih.gov/pubmed/32620852
http://dx.doi.org/10.1038/s41598-020-67348-0
work_keys_str_mv AT theiligdorothea impactofquantitativepulmonaryemphysemascoreontherateofpneumothoraxandchesttubeinsertioninctguidedlungbiopsies
AT petscheltdavid impactofquantitativepulmonaryemphysemascoreontherateofpneumothoraxandchesttubeinsertioninctguidedlungbiopsies
AT mayerhoferanna impactofquantitativepulmonaryemphysemascoreontherateofpneumothoraxandchesttubeinsertioninctguidedlungbiopsies
AT hammbernd impactofquantitativepulmonaryemphysemascoreontherateofpneumothoraxandchesttubeinsertioninctguidedlungbiopsies
AT gebauerbernhard impactofquantitativepulmonaryemphysemascoreontherateofpneumothoraxandchesttubeinsertioninctguidedlungbiopsies
AT geiseldominik impactofquantitativepulmonaryemphysemascoreontherateofpneumothoraxandchesttubeinsertioninctguidedlungbiopsies