Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target

Pancreatic ductal adenocarcinoma (PDAC) lethality is due to metastatic dissemination. Characterization of rare, heterogeneous circulating tumor cells (CTCs) can provide insight into metastasis and guide development of novel therapies. Using the CTC-iChip to purify CTCs from PDAC patients for RNA-seq...

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Detalles Bibliográficos
Autores principales: Franses, Joseph W., Philipp, Julia, Missios, Pavlos, Bhan, Irun, Liu, Ann, Yashaswini, Chittampalli, Tai, Eric, Zhu, Huili, Ligorio, Matteo, Nicholson, Benjamin, Tassoni, Elizabeth M., Desai, Niyati, Kulkarni, Anupriya S., Szabolcs, Annamaria, Hong, Theodore S., Liss, Andrew S., Fernandez-del Castillo, Carlos, Ryan, David P., Maheswaran, Shyamala, Haber, Daniel A., Daley, George Q., Ting, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335061/
https://www.ncbi.nlm.nih.gov/pubmed/32620742
http://dx.doi.org/10.1038/s41467-020-17150-3

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