Cargando…

Subtyping analysis reveals new variants and accelerated evolution of Clostridioides difficile toxin B

Clostridioides difficile toxins (TcdA and TcdB) are major exotoxins responsible for C. difficile infection (CDI) associated diseases. The previously reported TcdB variants showed distinct biological features, immunoactivities, and potential pathogenicity in disease progression. Here, we performed gl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shen, Enhui, Zhu, Kangli, Li, Danyang, Pan, Zhenrui, Luo, Yun, Bian, Qiao, He, Liuqing, Song, Xiaojun, Zhen, Ying, Jin, Dazhi, Tao, Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335066/ https://www.ncbi.nlm.nih.gov/pubmed/32620855 http://dx.doi.org/10.1038/s42003-020-1078-y

Ejemplares similares

Functional analyses of epidemic Clostridioides difficile toxin B variants reveal their divergence in utilizing receptors and inducing pathology
por: Pan, Zhenrui, et al.
Publicado: (2021)

An Atypical Case of Monomicrobial Clostridioides difficile Septicemia With No Gastrointestinal Manifestations
por: Wang, Liqian, et al.
Publicado: (2022)

An Update on Clostridioides difficile Binary Toxin
por: Martínez-Meléndez, Adrián, et al.
Publicado: (2022)

Genomic evolution and virulence association of Clostridioides difficile sequence type 37 (ribotype 017) in China
por: Xu, Xingxing, et al.
Publicado: (2021)

Comparative genomics of Clostridioides difficile toxinotypes identifies module-based toxin gene evolution
por: Janezic, Sandra, et al.
Publicado: (2020)

The prognostic value of toxin B and binary toxin in Clostridioides difficile infection
por: López-Cárdenas, Salvador, et al.
Publicado: (2021)

Host Immune Responses to Clostridioides difficile: Toxins and Beyond
por: Nibbering, Britt, et al.
Publicado: (2021)

Structure and conformational dynamics of Clostridioides difficile toxin A
por: Chen, Baohua, et al.
Publicado: (2022)

Non-Toxin-Based Clostridioides difficile Vaccination Approaches
por: Razim, Agnieszka, et al.
Publicado: (2023)

Diversity of binary toxin positive Clostridioides difficile in Korea
por: Kim, Jieun, et al.
Publicado: (2023)

Comparative Whole Genome Sequence Analysis and Biological Features of Clostridioides difficile Sequence Type 2(‡)
por: Xu, Xingxing, et al.
Publicado: (2021)

High-Level Resistance of Toxigenic Clostridioides difficile Genotype to Macrolide-Lincosamide- Streptogramin B in Community Acquired Patients in Eastern China
por: Zhao, Longyou, et al.
Publicado: (2020)

Impact of deoxycholate on Clostridioides difficile growth, toxin production, and sporulation
por: Usui, Yukino, et al.
Publicado: (2020)

The Importance of Therapeutically Targeting the Binary Toxin from Clostridioides difficile
por: Abeyawardhane, Dinendra L., et al.
Publicado: (2021)

Binary Toxin Expression by Clostridioides difficile Is Associated With Worse Disease
por: Young, Mary K, et al.
Publicado: (2022)

Iron Effects on Clostridioides difficile Toxin Production and Antimicrobial Susceptibilities
por: Yamaki, Jason, et al.
Publicado: (2022)

Tauroursodeoxycholic Acid Inhibits Clostridioides difficile Toxin-Induced Apoptosis
por: Pike, Colleen M., et al.
Publicado: (2022)

The cytotoxic synergy between Clostridioides difficile toxin B and proinflammatory cytokines: an unholy alliance favoring the onset of Clostridioides difficile infection and relapses
por: Bassotti, Gabrio, et al.
Publicado: (2020)

Inhibition of Clostridioides difficile Toxins TcdA and TcdB by Ambroxol
por: Heber, Sebastian, et al.
Publicado: (2022)

Glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins during infection
por: Peritore-Galve, F. Christopher, et al.
Publicado: (2022)

Characterization and Pharmacological Inhibition of the Pore-Forming Clostridioides difficile CDTb Toxin
por: Ernst, Katharina, et al.
Publicado: (2021)

Structural Basis for Binding of Neutralizing Antibodies to Clostridioides difficile Binary Toxin
por: Goldsmith, Jory A., et al.
Publicado: (2023)

The TcdE holin drives toxin secretion and virulence in Clostridioides difficile
por: DiBenedetto, NV, et al.
Publicado: (2023)

Make It Less difficile: Understanding Genetic Evolution and Global Spread of Clostridioides difficile
por: Mengoli, Mariachiara, et al.
Publicado: (2022)

Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B
por: Mansfield, Michael J., et al.
Publicado: (2020)

Extraintestinal Clostridioides difficile infection
por: Hai, Zhao, et al.
Publicado: (2020)

Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants
por: Tian, Songhai, et al.
Publicado: (2022)

Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B
por: Schöttelndreier, Dennis, et al.
Publicado: (2018)

Metabolic Reprogramming of Clostridioides difficile During the Stationary Phase With the Induction of Toxin Production
por: Hofmann, Julia D., et al.
Publicado: (2018)

RstA Is a Major Regulator of Clostridioides difficile Toxin Production and Motility
por: Edwards, Adrianne N., et al.
Publicado: (2019)

The Conserved Cys-2232 in Clostridioides difficile Toxin B Modulates Receptor Binding
por: Chung, Soo-Young, et al.
Publicado: (2018)

Eosinopenia and Binary Toxin Increase Mortality in Hospitalized Patients With Clostridioides difficile Infection
por: Carlson, Travis J, et al.
Publicado: (2020)

Structural Insights into the Transition of Clostridioides difficile Binary Toxin from Prepore to Pore
por: Anderson, David M., et al.
Publicado: (2019)

2398. Effect of Eosinopenia and Binary Toxin on Clostridioides difficile Infection Clinical Outcomes
por: Carlson, Travis J, et al.
Publicado: (2019)

The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells
por: Stieglitz, Florian, et al.
Publicado: (2021)

Proinflammatory Cytokines: Possible Accomplices for the Systemic Effects of Clostridioides difficile Toxin B
por: Fettucciari, Katia, et al.
Publicado: (2021)

Low-toxin Clostridioides difficile RT027 strains exhibit robust virulence
por: Anwar, Farhan, et al.
Publicado: (2022)

Structure-guided design of a potent Clostridioides difficile toxin A inhibitor
por: Hussack, Greg, et al.
Publicado: (2023)

386. Clostridioides difficile PCR Cycle Threshold to Determine Toxin Positivity Status
por: Crone, Andrew S, et al.
Publicado: (2022)

Network analysis of toxin production in Clostridioides difficile identifies key metabolic dependencies
por: Powers, Deborah A., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_nft4oki68475qk8d2o5t995a55