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Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms

Mammalian DNA methylation patterns are established by two de novo DNA methyltransferases, DNMT3A and DNMT3B, which exhibit both redundant and distinctive methylation activities. However, the related molecular basis remains undetermined. Through comprehensive structural, enzymology and cellular chara...

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Detalles Bibliográficos
Autores principales:	Gao, Linfeng, Emperle, Max, Guo, Yiran, Grimm, Sara A., Ren, Wendan, Adam, Sabrina, Uryu, Hidetaka, Zhang, Zhi-Min, Chen, Dongliang, Yin, Jiekai, Dukatz, Michael, Anteneh, Hiwot, Jurkowska, Renata Z., Lu, Jiuwei, Wang, Yinsheng, Bashtrykov, Pavel, Wade, Paul A., Wang, Gang Greg, Jeltsch, Albert, Song, Jikui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335073/ https://www.ncbi.nlm.nih.gov/pubmed/32620778 http://dx.doi.org/10.1038/s41467-020-17109-4

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