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Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion

Chromosomal NUP98-PHF23 translocation is associated with an aggressive form of acute myeloid leukemia (AML) and poor survival rate. Here, we report the molecular mechanisms by which NUP98-PHF23 recognizes the histone mark H3K4me3 and is inhibited by small molecule compounds, including disulfiram tha...

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Detalles Bibliográficos
Autores principales:	Zhang, Yi, Guo, Yiran, Gough, Sheryl M., Zhang, Jinyong, Vann, Kendra R., Li, Kuai, Cai, Ling, Shi, Xiaobing, Aplan, Peter D., Wang, Gang Greg, Kutateladze, Tatiana G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335091/ https://www.ncbi.nlm.nih.gov/pubmed/32620764 http://dx.doi.org/10.1038/s41467-020-17098-4

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