FBXO45 is a potential therapeutic target for cancer therapy

FBXO protein 45 (FBXO45), a substrate-recognition subunit of E3 ligases, has been characterised to have pivotal roles in many human diseases, including nervous system diseases, inflammatory diseases and human malignancies. In this article, we describe the expression of FBXO45 in several types of hum...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Min, Wang, Zhi-wei, Zhu, Xueqiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335190/
https://www.ncbi.nlm.nih.gov/pubmed/32655893
http://dx.doi.org/10.1038/s41420-020-0291-2
_version_ 1783554091963645952
author Lin, Min
Wang, Zhi-wei
Zhu, Xueqiong
author_facet Lin, Min
Wang, Zhi-wei
Zhu, Xueqiong
author_sort Lin, Min
collection PubMed
description FBXO protein 45 (FBXO45), a substrate-recognition subunit of E3 ligases, has been characterised to have pivotal roles in many human diseases, including nervous system diseases, inflammatory diseases and human malignancies. In this article, we describe the expression of FBXO45 in several types of human tumour specimens and highlight the downstream substrates of FBXO45. Moreover, the biological functions of FBXO45 in the regulation of proliferation, apoptosis, the cell cycle and metastasis are mentioned. Furthermore, we describe that the expression level of FBXO45 is regulated by several upstream factors such as miR-27a, Hey1, m(6)A and the lncRNA RP11. As FBXO45 has a critical role in tumorigenesis and progression, FBXO45 might be a novel therapeutic target for cancer treatment.
format Online
Article
Text
id pubmed-7335190
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-73351902020-07-09 FBXO45 is a potential therapeutic target for cancer therapy Lin, Min Wang, Zhi-wei Zhu, Xueqiong Cell Death Discov Perspective FBXO protein 45 (FBXO45), a substrate-recognition subunit of E3 ligases, has been characterised to have pivotal roles in many human diseases, including nervous system diseases, inflammatory diseases and human malignancies. In this article, we describe the expression of FBXO45 in several types of human tumour specimens and highlight the downstream substrates of FBXO45. Moreover, the biological functions of FBXO45 in the regulation of proliferation, apoptosis, the cell cycle and metastasis are mentioned. Furthermore, we describe that the expression level of FBXO45 is regulated by several upstream factors such as miR-27a, Hey1, m(6)A and the lncRNA RP11. As FBXO45 has a critical role in tumorigenesis and progression, FBXO45 might be a novel therapeutic target for cancer treatment. Nature Publishing Group UK 2020-07-03 /pmc/articles/PMC7335190/ /pubmed/32655893 http://dx.doi.org/10.1038/s41420-020-0291-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Perspective
Lin, Min
Wang, Zhi-wei
Zhu, Xueqiong
FBXO45 is a potential therapeutic target for cancer therapy
title FBXO45 is a potential therapeutic target for cancer therapy
title_full FBXO45 is a potential therapeutic target for cancer therapy
title_fullStr FBXO45 is a potential therapeutic target for cancer therapy
title_full_unstemmed FBXO45 is a potential therapeutic target for cancer therapy
title_short FBXO45 is a potential therapeutic target for cancer therapy
title_sort fbxo45 is a potential therapeutic target for cancer therapy
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335190/
https://www.ncbi.nlm.nih.gov/pubmed/32655893
http://dx.doi.org/10.1038/s41420-020-0291-2
work_keys_str_mv AT linmin fbxo45isapotentialtherapeutictargetforcancertherapy
AT wangzhiwei fbxo45isapotentialtherapeutictargetforcancertherapy
AT zhuxueqiong fbxo45isapotentialtherapeutictargetforcancertherapy

Ejemplares similares