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Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities
The amyloid conformation can be adopted by a variety of sequences, but the precise boundaries of amyloid sequence space are still unclear. The currently charted amyloid sequence space is strongly biased towards hydrophobic, beta-sheet prone sequences that form the core of globular proteins and by Q/...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335209/ https://www.ncbi.nlm.nih.gov/pubmed/32620861 http://dx.doi.org/10.1038/s41467-020-17207-3 |