Structure of avian influenza hemagglutinin in complex with a small molecule entry inhibitor

HA plays a critical role in influenza infection and, thus HA is a potential target for antivirals. Recently, our laboratories have described a novel fusion inhibitor, termed CBS1117, with EC(50) ∼3 μM against group 1 HA. In this work, we characterize the binding properties of CBS1117 to avian H5 HA...

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Detalles Bibliográficos
Autores principales: Antanasijevic, Aleksandar, Durst, Matthew A, Cheng, Han, Gaisina, Irina N, Perez, Jasmine T, Manicassamy, Balaji, Rong, Lijun, Lavie, Arnon, Caffrey, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335401/
https://www.ncbi.nlm.nih.gov/pubmed/32611549
http://dx.doi.org/10.26508/lsa.202000724

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335401/
https://www.ncbi.nlm.nih.gov/pubmed/32611549
http://dx.doi.org/10.26508/lsa.202000724

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