Evaluation and Minimization of Cas9-Independent Off-Target DNA Editing by Cytosine Base Editors

Cytosine base editors (CBEs) enable targeted C•G-to-T•A conversions in genomic DNA. Recent studies report that BE3, the original CBE, induces a low frequency of genome-wide Cas9-independent off-target C•G-to-T•A deamination in mouse embryos and in rice. Here we develop multiple rapid, cost-effective...

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Detalles Bibliográficos
Autores principales: Doman, Jordan L., Raguram, Aditya, Newby, Gregory A., Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335424/
https://www.ncbi.nlm.nih.gov/pubmed/32042165
http://dx.doi.org/10.1038/s41587-020-0414-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335424/
https://www.ncbi.nlm.nih.gov/pubmed/32042165
http://dx.doi.org/10.1038/s41587-020-0414-6

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