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Evaluation and Minimization of Cas9-Independent Off-Target DNA Editing by Cytosine Base Editors
Cytosine base editors (CBEs) enable targeted C•G-to-T•A conversions in genomic DNA. Recent studies report that BE3, the original CBE, induces a low frequency of genome-wide Cas9-independent off-target C•G-to-T•A deamination in mouse embryos and in rice. Here we develop multiple rapid, cost-effective...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335424/ https://www.ncbi.nlm.nih.gov/pubmed/32042165 http://dx.doi.org/10.1038/s41587-020-0414-6 |