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Glycemic variability: adverse clinical outcomes and how to improve it?

Glycemic variability (GV), defined as an integral component of glucose homoeostasis, is emerging as an important metric to consider when assessing glycemic control in clinical practice. Although it remains yet no consensus, accumulating evidence has suggested that GV, representing either short-term...

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Autores principales: Zhou, Zheng, Sun, Bao, Huang, Shiqiong, Zhu, Chunsheng, Bian, Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335439/
https://www.ncbi.nlm.nih.gov/pubmed/32622354
http://dx.doi.org/10.1186/s12933-020-01085-6
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author Zhou, Zheng
Sun, Bao
Huang, Shiqiong
Zhu, Chunsheng
Bian, Meng
author_facet Zhou, Zheng
Sun, Bao
Huang, Shiqiong
Zhu, Chunsheng
Bian, Meng
author_sort Zhou, Zheng
collection PubMed
description Glycemic variability (GV), defined as an integral component of glucose homoeostasis, is emerging as an important metric to consider when assessing glycemic control in clinical practice. Although it remains yet no consensus, accumulating evidence has suggested that GV, representing either short-term (with-day and between-day variability) or long-term GV, was associated with an increased risk of diabetic macrovascular and microvascular complications, hypoglycemia, mortality rates and other adverse clinical outcomes. In this review, we summarize the adverse clinical outcomes of GV and discuss the beneficial measures, including continuous glucose monitoring, drugs, dietary interventions and exercise training, to improve it, aiming at better addressing the challenging aspect of blood glucose management.
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spelling pubmed-73354392020-07-07 Glycemic variability: adverse clinical outcomes and how to improve it? Zhou, Zheng Sun, Bao Huang, Shiqiong Zhu, Chunsheng Bian, Meng Cardiovasc Diabetol Review Glycemic variability (GV), defined as an integral component of glucose homoeostasis, is emerging as an important metric to consider when assessing glycemic control in clinical practice. Although it remains yet no consensus, accumulating evidence has suggested that GV, representing either short-term (with-day and between-day variability) or long-term GV, was associated with an increased risk of diabetic macrovascular and microvascular complications, hypoglycemia, mortality rates and other adverse clinical outcomes. In this review, we summarize the adverse clinical outcomes of GV and discuss the beneficial measures, including continuous glucose monitoring, drugs, dietary interventions and exercise training, to improve it, aiming at better addressing the challenging aspect of blood glucose management. BioMed Central 2020-07-04 /pmc/articles/PMC7335439/ /pubmed/32622354 http://dx.doi.org/10.1186/s12933-020-01085-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhou, Zheng
Sun, Bao
Huang, Shiqiong
Zhu, Chunsheng
Bian, Meng
Glycemic variability: adverse clinical outcomes and how to improve it?
title Glycemic variability: adverse clinical outcomes and how to improve it?
title_full Glycemic variability: adverse clinical outcomes and how to improve it?
title_fullStr Glycemic variability: adverse clinical outcomes and how to improve it?
title_full_unstemmed Glycemic variability: adverse clinical outcomes and how to improve it?
title_short Glycemic variability: adverse clinical outcomes and how to improve it?
title_sort glycemic variability: adverse clinical outcomes and how to improve it?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335439/
https://www.ncbi.nlm.nih.gov/pubmed/32622354
http://dx.doi.org/10.1186/s12933-020-01085-6
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