SARS-CoV2 envelope protein: non-synonymous mutations and its consequences

In the NCBI database, as on June 6, 2020, total number of available complete genome sequences of SARS-CoV2 across the world is 3617. The envelope (E) protein of SARS-CoV2 possesses several non-synonymous mutations over the transmembrane and C-terminus domains in 15 (0.414%) genomes among 3617 SARS-C...

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Autores principales: Hassan, Sk. Sarif, Choudhury, Pabitra Pal, Roy, Bidyut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335631/
https://www.ncbi.nlm.nih.gov/pubmed/32640274
http://dx.doi.org/10.1016/j.ygeno.2020.07.001
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author Hassan, Sk. Sarif
Choudhury, Pabitra Pal
Roy, Bidyut
author_facet Hassan, Sk. Sarif
Choudhury, Pabitra Pal
Roy, Bidyut
author_sort Hassan, Sk. Sarif
collection PubMed
description In the NCBI database, as on June 6, 2020, total number of available complete genome sequences of SARS-CoV2 across the world is 3617. The envelope (E) protein of SARS-CoV2 possesses several non-synonymous mutations over the transmembrane and C-terminus domains in 15 (0.414%) genomes among 3617 SARS-CoV2 genomes, analyzed. More precisely, 10(0.386%) out of 2588 genomes from the USA, 3(0.806%) from Asia, 1 (0.348%) from Europe and 1 (0.274%) from Oceania contained the missense mutations over the E-protein of SARS-CoV2 genomes. The C-terminus motif DLLV has been to DFLV and YLLV in the proteins from QJR88103 (Australia: Victoria) and QKI36831 (China: Guangzhou) respectively, which might affect the binding of this motif with the host protein PALS1.
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spelling pubmed-73356312020-07-06 SARS-CoV2 envelope protein: non-synonymous mutations and its consequences Hassan, Sk. Sarif Choudhury, Pabitra Pal Roy, Bidyut Genomics Article In the NCBI database, as on June 6, 2020, total number of available complete genome sequences of SARS-CoV2 across the world is 3617. The envelope (E) protein of SARS-CoV2 possesses several non-synonymous mutations over the transmembrane and C-terminus domains in 15 (0.414%) genomes among 3617 SARS-CoV2 genomes, analyzed. More precisely, 10(0.386%) out of 2588 genomes from the USA, 3(0.806%) from Asia, 1 (0.348%) from Europe and 1 (0.274%) from Oceania contained the missense mutations over the E-protein of SARS-CoV2 genomes. The C-terminus motif DLLV has been to DFLV and YLLV in the proteins from QJR88103 (Australia: Victoria) and QKI36831 (China: Guangzhou) respectively, which might affect the binding of this motif with the host protein PALS1. Elsevier Inc. 2020-11 2020-07-05 /pmc/articles/PMC7335631/ /pubmed/32640274 http://dx.doi.org/10.1016/j.ygeno.2020.07.001 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Hassan, Sk. Sarif
Choudhury, Pabitra Pal
Roy, Bidyut
SARS-CoV2 envelope protein: non-synonymous mutations and its consequences
title SARS-CoV2 envelope protein: non-synonymous mutations and its consequences
title_full SARS-CoV2 envelope protein: non-synonymous mutations and its consequences
title_fullStr SARS-CoV2 envelope protein: non-synonymous mutations and its consequences
title_full_unstemmed SARS-CoV2 envelope protein: non-synonymous mutations and its consequences
title_short SARS-CoV2 envelope protein: non-synonymous mutations and its consequences
title_sort sars-cov2 envelope protein: non-synonymous mutations and its consequences
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335631/
https://www.ncbi.nlm.nih.gov/pubmed/32640274
http://dx.doi.org/10.1016/j.ygeno.2020.07.001
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