Autophagy-Related Beclin 1 and Head and Neck Cancers

Beclin 1, a positive regulator of autophagy, behaves as a double-edged sword in tumorigenesis. Beclin 1 contributes to tumor suppression by removing defective or damaged organelles and other cellular components; however, its activity can also stimulate cancer initiation and progression. In head and...

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Autores principales: Hu, Yang-Jie, Zhong, Jiang-Tao, Gong, Liang, Zhang, Si-Cong, Zhou, Shui-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335767/
https://www.ncbi.nlm.nih.gov/pubmed/32669852
http://dx.doi.org/10.2147/OTT.S256072
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author Hu, Yang-Jie
Zhong, Jiang-Tao
Gong, Liang
Zhang, Si-Cong
Zhou, Shui-Hong
author_facet Hu, Yang-Jie
Zhong, Jiang-Tao
Gong, Liang
Zhang, Si-Cong
Zhou, Shui-Hong
author_sort Hu, Yang-Jie
collection PubMed
description Beclin 1, a positive regulator of autophagy, behaves as a double-edged sword in tumorigenesis. Beclin 1 contributes to tumor suppression by removing defective or damaged organelles and other cellular components; however, its activity can also stimulate cancer initiation and progression. In head and neck cancer, Beclin 1 overexpression promotes autophagy, which limits DNA damage and chromosomal instability and increases necrosis and inflammation by impacting apoptotic and autophagic pathways. This paper reviews the relationship between Beclin 1, carcinogenesis and head and neck cancer prognosis.
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spelling pubmed-73357672020-07-14 Autophagy-Related Beclin 1 and Head and Neck Cancers Hu, Yang-Jie Zhong, Jiang-Tao Gong, Liang Zhang, Si-Cong Zhou, Shui-Hong Onco Targets Ther Review Beclin 1, a positive regulator of autophagy, behaves as a double-edged sword in tumorigenesis. Beclin 1 contributes to tumor suppression by removing defective or damaged organelles and other cellular components; however, its activity can also stimulate cancer initiation and progression. In head and neck cancer, Beclin 1 overexpression promotes autophagy, which limits DNA damage and chromosomal instability and increases necrosis and inflammation by impacting apoptotic and autophagic pathways. This paper reviews the relationship between Beclin 1, carcinogenesis and head and neck cancer prognosis. Dove 2020-06-30 /pmc/articles/PMC7335767/ /pubmed/32669852 http://dx.doi.org/10.2147/OTT.S256072 Text en © 2020 Hu et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Hu, Yang-Jie
Zhong, Jiang-Tao
Gong, Liang
Zhang, Si-Cong
Zhou, Shui-Hong
Autophagy-Related Beclin 1 and Head and Neck Cancers
title Autophagy-Related Beclin 1 and Head and Neck Cancers
title_full Autophagy-Related Beclin 1 and Head and Neck Cancers
title_fullStr Autophagy-Related Beclin 1 and Head and Neck Cancers
title_full_unstemmed Autophagy-Related Beclin 1 and Head and Neck Cancers
title_short Autophagy-Related Beclin 1 and Head and Neck Cancers
title_sort autophagy-related beclin 1 and head and neck cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335767/
https://www.ncbi.nlm.nih.gov/pubmed/32669852
http://dx.doi.org/10.2147/OTT.S256072
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