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Alteration of Liver Biomarkers in Patients with SARS-CoV-2 (COVID-19)

INTRODUCTION: Coronavirus disease 2019 (COVID-19) emerged in China and spread worldwide. In this study, we assessed the characteristics of markers of the liver in patients with COVID-19 to provide new insights in improving clinical treatment. PATIENTS AND METHODS: We recruited 279 patients who confi...

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Autores principales: Gholizadeh, Pourya, Safari, Rohollah, Marofi, Parham, Zeinalzadeh, Elham, Pagliano, Pasquale, Ganbarov, Khudaverdi, Esposito, Silvano, Khodadadi, Ehsaneh, Yousefi, Mehdi, Samadi Kafil, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335895/
https://www.ncbi.nlm.nih.gov/pubmed/32669866
http://dx.doi.org/10.2147/JIR.S257078
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author Gholizadeh, Pourya
Safari, Rohollah
Marofi, Parham
Zeinalzadeh, Elham
Pagliano, Pasquale
Ganbarov, Khudaverdi
Esposito, Silvano
Khodadadi, Ehsaneh
Yousefi, Mehdi
Samadi Kafil, Hossein
author_facet Gholizadeh, Pourya
Safari, Rohollah
Marofi, Parham
Zeinalzadeh, Elham
Pagliano, Pasquale
Ganbarov, Khudaverdi
Esposito, Silvano
Khodadadi, Ehsaneh
Yousefi, Mehdi
Samadi Kafil, Hossein
author_sort Gholizadeh, Pourya
collection PubMed
description INTRODUCTION: Coronavirus disease 2019 (COVID-19) emerged in China and spread worldwide. In this study, we assessed the characteristics of markers of the liver in patients with COVID-19 to provide new insights in improving clinical treatment. PATIENTS AND METHODS: We recruited 279 patients who confirmed COVID-19 and the data of liver biomarkers and complete blood count of patients were defined as the day onset when the patients admitted to the hospital. RESULTS: The average of LDH value was 621.29 U/L in all patients with COVID-19, and CPK was 286.90 U/L. The average AST was 44.03 U/L in all patients, and ALT was 31.14 U/L. The AST/ALT ratio was 1.64 in all patients. The measurement of CRP was increased by 79.93% in all patients. Average ALT and AST values of patients with elevated ALT were significantly increased in comparison to patients with normal ALT (P-value = 0.001), while AST/ALT ratio was significantly decreased compared to patients with normal ALT (P-value= 0.014). In addition, the average LDH of patients with elevated ALT was significantly increased compared to patients with normal ALT (P-value = 0.014). CONCLUSION: Hepatic injury and abnormal liver enzymes related to COVID-19 infection is an acute non-specific inflammation alteration.
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spelling pubmed-73358952020-07-14 Alteration of Liver Biomarkers in Patients with SARS-CoV-2 (COVID-19) Gholizadeh, Pourya Safari, Rohollah Marofi, Parham Zeinalzadeh, Elham Pagliano, Pasquale Ganbarov, Khudaverdi Esposito, Silvano Khodadadi, Ehsaneh Yousefi, Mehdi Samadi Kafil, Hossein J Inflamm Res Original Research INTRODUCTION: Coronavirus disease 2019 (COVID-19) emerged in China and spread worldwide. In this study, we assessed the characteristics of markers of the liver in patients with COVID-19 to provide new insights in improving clinical treatment. PATIENTS AND METHODS: We recruited 279 patients who confirmed COVID-19 and the data of liver biomarkers and complete blood count of patients were defined as the day onset when the patients admitted to the hospital. RESULTS: The average of LDH value was 621.29 U/L in all patients with COVID-19, and CPK was 286.90 U/L. The average AST was 44.03 U/L in all patients, and ALT was 31.14 U/L. The AST/ALT ratio was 1.64 in all patients. The measurement of CRP was increased by 79.93% in all patients. Average ALT and AST values of patients with elevated ALT were significantly increased in comparison to patients with normal ALT (P-value = 0.001), while AST/ALT ratio was significantly decreased compared to patients with normal ALT (P-value= 0.014). In addition, the average LDH of patients with elevated ALT was significantly increased compared to patients with normal ALT (P-value = 0.014). CONCLUSION: Hepatic injury and abnormal liver enzymes related to COVID-19 infection is an acute non-specific inflammation alteration. Dove 2020-07-01 /pmc/articles/PMC7335895/ /pubmed/32669866 http://dx.doi.org/10.2147/JIR.S257078 Text en © 2020 Gholizadeh et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Gholizadeh, Pourya
Safari, Rohollah
Marofi, Parham
Zeinalzadeh, Elham
Pagliano, Pasquale
Ganbarov, Khudaverdi
Esposito, Silvano
Khodadadi, Ehsaneh
Yousefi, Mehdi
Samadi Kafil, Hossein
Alteration of Liver Biomarkers in Patients with SARS-CoV-2 (COVID-19)
title Alteration of Liver Biomarkers in Patients with SARS-CoV-2 (COVID-19)
title_full Alteration of Liver Biomarkers in Patients with SARS-CoV-2 (COVID-19)
title_fullStr Alteration of Liver Biomarkers in Patients with SARS-CoV-2 (COVID-19)
title_full_unstemmed Alteration of Liver Biomarkers in Patients with SARS-CoV-2 (COVID-19)
title_short Alteration of Liver Biomarkers in Patients with SARS-CoV-2 (COVID-19)
title_sort alteration of liver biomarkers in patients with sars-cov-2 (covid-19)
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335895/
https://www.ncbi.nlm.nih.gov/pubmed/32669866
http://dx.doi.org/10.2147/JIR.S257078
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