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Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, February and March 2020
We whole-genome sequenced 55 SARS-CoV-2 isolates from Germany to investigate SARS-CoV-2 outbreaks in 2020 in the Heinsberg district and Düsseldorf. While the genetic structure of the Heinsberg outbreak indicates a clonal origin, reflecting superspreading dynamics from mid-February during the carniva...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336109/ https://www.ncbi.nlm.nih.gov/pubmed/32524946 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.22.2000746 |
| _version_ | 1783554250605854720 |
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| author | Walker, Andreas Houwaart, Torsten Wienemann, Tobias Vasconcelos, Malte Kohns Strelow, Daniel Senff, Tina Hülse, Lisanna Adams, Ortwin Andree, Marcel Hauka, Sandra Feldt, Torsten Jensen, Björn-Erik Keitel, Verena Kindgen-Milles, Detlef Timm, Jörg Pfeffer, Klaus Dilthey, Alexander T |
| author_facet | Walker, Andreas Houwaart, Torsten Wienemann, Tobias Vasconcelos, Malte Kohns Strelow, Daniel Senff, Tina Hülse, Lisanna Adams, Ortwin Andree, Marcel Hauka, Sandra Feldt, Torsten Jensen, Björn-Erik Keitel, Verena Kindgen-Milles, Detlef Timm, Jörg Pfeffer, Klaus Dilthey, Alexander T |
| author_sort | Walker, Andreas |
| collection | PubMed |
| description | We whole-genome sequenced 55 SARS-CoV-2 isolates from Germany to investigate SARS-CoV-2 outbreaks in 2020 in the Heinsberg district and Düsseldorf. While the genetic structure of the Heinsberg outbreak indicates a clonal origin, reflecting superspreading dynamics from mid-February during the carnival season, distinct viral strains were circulating in Düsseldorf in March, reflecting the city’s international links. Limited detection of Heinsberg strains in the Düsseldorf area despite geographical proximity may reflect efficient containment and contact-tracing efforts. |
| format | Online Article Text |
| id | pubmed-7336109 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | European Centre for Disease Prevention and Control (ECDC) |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-73361092020-07-09 Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, February and March 2020 Walker, Andreas Houwaart, Torsten Wienemann, Tobias Vasconcelos, Malte Kohns Strelow, Daniel Senff, Tina Hülse, Lisanna Adams, Ortwin Andree, Marcel Hauka, Sandra Feldt, Torsten Jensen, Björn-Erik Keitel, Verena Kindgen-Milles, Detlef Timm, Jörg Pfeffer, Klaus Dilthey, Alexander T Euro Surveill Rapid Communication We whole-genome sequenced 55 SARS-CoV-2 isolates from Germany to investigate SARS-CoV-2 outbreaks in 2020 in the Heinsberg district and Düsseldorf. While the genetic structure of the Heinsberg outbreak indicates a clonal origin, reflecting superspreading dynamics from mid-February during the carnival season, distinct viral strains were circulating in Düsseldorf in March, reflecting the city’s international links. Limited detection of Heinsberg strains in the Düsseldorf area despite geographical proximity may reflect efficient containment and contact-tracing efforts. European Centre for Disease Prevention and Control (ECDC) 2020-06-04 /pmc/articles/PMC7336109/ /pubmed/32524946 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.22.2000746 Text en This article is copyright of the authors or their affiliated institutions, 2020. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
| spellingShingle | Rapid Communication Walker, Andreas Houwaart, Torsten Wienemann, Tobias Vasconcelos, Malte Kohns Strelow, Daniel Senff, Tina Hülse, Lisanna Adams, Ortwin Andree, Marcel Hauka, Sandra Feldt, Torsten Jensen, Björn-Erik Keitel, Verena Kindgen-Milles, Detlef Timm, Jörg Pfeffer, Klaus Dilthey, Alexander T Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, February and March 2020 |
| title | Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, February and March 2020 |
| title_full | Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, February and March 2020 |
| title_fullStr | Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, February and March 2020 |
| title_full_unstemmed | Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, February and March 2020 |
| title_short | Genetic structure of SARS-CoV-2 reflects clonal superspreading and multiple independent introduction events, North-Rhine Westphalia, Germany, February and March 2020 |
| title_sort | genetic structure of sars-cov-2 reflects clonal superspreading and multiple independent introduction events, north-rhine westphalia, germany, february and march 2020 |
| topic | Rapid Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336109/ https://www.ncbi.nlm.nih.gov/pubmed/32524946 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.22.2000746 |
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