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Breakdown of the affective‐cognitive network in functional dystonia

Previous studies suggested that brain regions subtending affective‐cognitive processes can be implicated in the pathophysiology of functional dystonia (FD). In this study, the role of the affective‐cognitive network was explored in two phenotypes of FD: fixed (FixFD) and mobile dystonia (MobFD). We...

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Autores principales: Canu, Elisa, Agosta, Federica, Tomic, Aleksandra, Sarasso, Elisabetta, Petrovic, Igor, Piramide, Noemi, Svetel, Marina, Inuggi, Alberto, D. Miskovic, Natasa, Kostic, Vladimir S., Filippi, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336141/
https://www.ncbi.nlm.nih.gov/pubmed/32243055
http://dx.doi.org/10.1002/hbm.24997
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author Canu, Elisa
Agosta, Federica
Tomic, Aleksandra
Sarasso, Elisabetta
Petrovic, Igor
Piramide, Noemi
Svetel, Marina
Inuggi, Alberto
D. Miskovic, Natasa
Kostic, Vladimir S.
Filippi, Massimo
author_facet Canu, Elisa
Agosta, Federica
Tomic, Aleksandra
Sarasso, Elisabetta
Petrovic, Igor
Piramide, Noemi
Svetel, Marina
Inuggi, Alberto
D. Miskovic, Natasa
Kostic, Vladimir S.
Filippi, Massimo
author_sort Canu, Elisa
collection PubMed
description Previous studies suggested that brain regions subtending affective‐cognitive processes can be implicated in the pathophysiology of functional dystonia (FD). In this study, the role of the affective‐cognitive network was explored in two phenotypes of FD: fixed (FixFD) and mobile dystonia (MobFD). We hypothesized that each of these phenotypes would show peculiar functional connectivity (FC) alterations in line with their divergent disease clinical expressions. Resting state fMRI (RS‐fMRI) was obtained in 40 FD patients (12 FixFD; 28 MobFD) and 43 controls (14 young FixFD‐age‐matched [yHC]; 29 old MobFD‐age‐matched [oHC]). FC of brain regions of interest, known to be involved in affective‐cognitive processes, and independent component analysis of RS‐fMRI data to explore brain networks were employed. Compared to HC, all FD patients showed reduced FC between the majority of affective‐cognitive seeds of interest and the fronto‐subcortical and limbic circuits; enhanced FC between the right affective‐cognitive part of the cerebellum and the bilateral associative parietal cortex; enhanced FC of the bilateral amygdala with the subcortical and posterior cortical brain regions; and altered FC between the left medial dorsal nucleus and the sensorimotor and associative brain regions (enhanced in MobFD and reduced in FixFD). Compared with yHC and MobFD patients, FixFD patients had an extensive pattern of reduced FC within the cerebellar network, and between the majority of affective‐cognitive seeds of interest and the sensorimotor and high‐order function (“cognitive”) areas with a unique involvement of dorsal anterior cingulate cortex connectivity. Brain FC within the affective‐cognitive network is altered in FD and presented specific features associated with each FD phenotype, suggesting an interaction between brain connectivity and clinical expression of the disease.
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spelling pubmed-73361412020-07-08 Breakdown of the affective‐cognitive network in functional dystonia Canu, Elisa Agosta, Federica Tomic, Aleksandra Sarasso, Elisabetta Petrovic, Igor Piramide, Noemi Svetel, Marina Inuggi, Alberto D. Miskovic, Natasa Kostic, Vladimir S. Filippi, Massimo Hum Brain Mapp Research Articles Previous studies suggested that brain regions subtending affective‐cognitive processes can be implicated in the pathophysiology of functional dystonia (FD). In this study, the role of the affective‐cognitive network was explored in two phenotypes of FD: fixed (FixFD) and mobile dystonia (MobFD). We hypothesized that each of these phenotypes would show peculiar functional connectivity (FC) alterations in line with their divergent disease clinical expressions. Resting state fMRI (RS‐fMRI) was obtained in 40 FD patients (12 FixFD; 28 MobFD) and 43 controls (14 young FixFD‐age‐matched [yHC]; 29 old MobFD‐age‐matched [oHC]). FC of brain regions of interest, known to be involved in affective‐cognitive processes, and independent component analysis of RS‐fMRI data to explore brain networks were employed. Compared to HC, all FD patients showed reduced FC between the majority of affective‐cognitive seeds of interest and the fronto‐subcortical and limbic circuits; enhanced FC between the right affective‐cognitive part of the cerebellum and the bilateral associative parietal cortex; enhanced FC of the bilateral amygdala with the subcortical and posterior cortical brain regions; and altered FC between the left medial dorsal nucleus and the sensorimotor and associative brain regions (enhanced in MobFD and reduced in FixFD). Compared with yHC and MobFD patients, FixFD patients had an extensive pattern of reduced FC within the cerebellar network, and between the majority of affective‐cognitive seeds of interest and the sensorimotor and high‐order function (“cognitive”) areas with a unique involvement of dorsal anterior cingulate cortex connectivity. Brain FC within the affective‐cognitive network is altered in FD and presented specific features associated with each FD phenotype, suggesting an interaction between brain connectivity and clinical expression of the disease. John Wiley & Sons, Inc. 2020-04-03 /pmc/articles/PMC7336141/ /pubmed/32243055 http://dx.doi.org/10.1002/hbm.24997 Text en © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Canu, Elisa
Agosta, Federica
Tomic, Aleksandra
Sarasso, Elisabetta
Petrovic, Igor
Piramide, Noemi
Svetel, Marina
Inuggi, Alberto
D. Miskovic, Natasa
Kostic, Vladimir S.
Filippi, Massimo
Breakdown of the affective‐cognitive network in functional dystonia
title Breakdown of the affective‐cognitive network in functional dystonia
title_full Breakdown of the affective‐cognitive network in functional dystonia
title_fullStr Breakdown of the affective‐cognitive network in functional dystonia
title_full_unstemmed Breakdown of the affective‐cognitive network in functional dystonia
title_short Breakdown of the affective‐cognitive network in functional dystonia
title_sort breakdown of the affective‐cognitive network in functional dystonia
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336141/
https://www.ncbi.nlm.nih.gov/pubmed/32243055
http://dx.doi.org/10.1002/hbm.24997
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