Cargando…

Hirudin Ameliorates Renal Interstitial Fibrosis via Regulating TGF-β1/Smad and NF-κB Signaling in UUO Rat Model

PURPOSE: Hirudin, a polypeptide structure containing 65 amino acids, is a potent natural thrombin inhibitor with anticoagulant property extracted from Hirudo medicinalis. It has been reported to have anti-inflammatory and antifibrotic property. Here we explored the renoprotective effect of hirudin o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Kang, Fan, Boya, Zhao, Qingyun, Ji, Yue, Liu, Panying, Gao, Shan, Ren, Tong, Dou, Yitian, Pei, Ming, Yang, Hongtao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336220/ https://www.ncbi.nlm.nih.gov/pubmed/32714415 http://dx.doi.org/10.1155/2020/7291075

Ejemplares similares

Transcriptome-Based Network Analysis Reveals Hirudin Potentiates Anti-Renal Fibrosis Efficacy in UUO Rats
por: Yu, Hang-Xing, et al.
Publicado: (2021)

Corni Fructus Alleviates UUO-Induced Renal Fibrosis via TGF-β/Smad Signaling
por: Lee, Jin A., et al.
Publicado: (2022)

Puerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-κB P65/STAT3 and TGFβ1/Smads Signaling Pathways
por: Wang, Jingyu, et al.
Publicado: (2021)

Ruxolitinib Alleviates Renal Interstitial Fibrosis in UUO Mice
por: Bai, Yu, et al.
Publicado: (2020)

Naringin attenuates renal interstitial fibrosis by regulating the TGF-β/Smad signaling pathway and inflammation
por: Wang, Ruichen, et al.
Publicado: (2021)

Hirudin ameliorates immunoglobulin A nephropathy by inhibition of fibrosis and inflammatory response
por: Deng, Fei, et al.
Publicado: (2019)

1,25-(OH)(2)D(3) ameliorates renal interstitial fibrosis in UUO rats through the AMPKα/mTOR pathway
por: Tian, Shasha, et al.
Publicado: (2021)

Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways
por: Lin, Liteng, et al.
Publicado: (2018)

N6-(2-Hydroxyethyl) Adenosine From Cordyceps cicadae Ameliorates Renal Interstitial Fibrosis and Prevents Inflammation via TGF-β1/Smad and NF-κB Signaling Pathway
por: Zheng, Rong, et al.
Publicado: (2018)

Mindin deficiency alleviates renal fibrosis through inhibiting NF‐κB and TGF‐β/Smad pathways
por: Yang, Kang, et al.
Publicado: (2020)

RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice
por: Zhou, Zhuanli, et al.
Publicado: (2020)

Wogonin Ameliorates Renal Inflammation and Fibrosis by Inhibiting NF-κB and TGF-β1/Smad3 Signaling Pathways in Diabetic Nephropathy
por: Zheng, Zhi-chao, et al.
Publicado: (2020)

Infusion of Phagocytic Macrophages Overexpressing CPT1a Ameliorates Kidney Fibrosis in the UUO Model
por: Calle, Priscila, et al.
Publicado: (2021)

Acupuncture attenuates renal interstitial fibrosis via the TGF-β/Smad pathway
por: Zuo, Zheng, et al.
Publicado: (2019)

Coreopsis tinctoria Nutt ameliorates high glucose-induced renal fibrosis and inflammation via the TGF-β1/SMADS/AMPK/NF-κB pathways
por: Yao, Lan, et al.
Publicado: (2019)

Isoliquiritigenin Attenuates UUO-Induced Renal Inflammation and Fibrosis by Inhibiting Mincle/Syk/NF-Kappa B Signaling Pathway
por: Liao, Yuan, et al.
Publicado: (2020)

NDRG2 Ameliorates Hepatic Fibrosis by Inhibiting the TGF-β1/Smad Pathway and Altering the MMP2/TIMP2 Ratio in Rats
por: Yang, Jiandong, et al.
Publicado: (2011)

Thymosin β4 alleviates renal fibrosis and tubular cell apoptosis through TGF-β pathway inhibition in UUO rat models
por: Yuan, Jing, et al.
Publicado: (2017)

Acetyl‐11‐keto‐β‐boswellic acid ameliorates renal interstitial fibrosis via Klotho/TGF‐β/Smad signalling pathway
por: Liu, Minna, et al.
Publicado: (2018)

DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice
por: Li, Xiaozhou, et al.
Publicado: (2020)

Shenqiwan Ameliorates Renal Fibrosis in Rats by Inhibiting TGF-β1/Smads Signaling Pathway
por: Chen, Hongshu, et al.
Publicado: (2017)

Combination of Active Components of Xiexin Decoction Ameliorates Renal Fibrosis Through the Inhibition of NF-κB and TGF-β1/Smad Pathways in db/db Diabetic Mice
por: Wu, Jia-Sheng, et al.
Publicado: (2015)

Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways
por: Li, Rui, et al.
Publicado: (2019)

Eplerenone Attenuates Fibrosis in the Contralateral Kidney of UUO Rats by Preventing Macrophage-to-Myofibroblast Transition
por: Xiong, Yunzhao, et al.
Publicado: (2021)

Chop deficiency prevents UUO-induced renal fibrosis by attenuating fibrotic signals originated from Hmgb1/TLR4/NFκB/IL-1β signaling
por: Zhang, M, et al.
Publicado: (2015)

S-allylmercapto-N-acetylcysteine ameliorates pulmonary fibrosis in mice via Nrf2 pathway activation and NF-κB, TGF-β1/Smad2/3 pathway suppression
por: Zhang, Qinxiu, et al.
Publicado: (2023)

Transcriptome Identified lncRNAs Associated with Renal Fibrosis in UUO Rat Model
por: Sun, Jiazeng, et al.
Publicado: (2017)

Fluorofenidone Inhibits UUO/IRI-Induced Renal Fibrosis by Reducing Mitochondrial Damage
por: Liao, Xiaohua, et al.
Publicado: (2022)

Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways
por: Feng, Jiao, et al.
Publicado: (2018)

Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway
por: Wang, Hui, et al.
Publicado: (2022)

Natural Hirudin Increases Rat Flap Viability by Anti-Inflammation via PARs/p38/NF-κB Pathway
por: Peng, Liu, et al.
Publicado: (2015)

Kirenol alleviates diabetic nephropathy via regulating TGF-β/Smads and the NF-κB signal pathway
por: Li, Jialin, et al.
Publicado: (2022)

Dendropanax morbifera Ameliorates Thioacetamide-Induced Hepatic Fibrosis via TGF-β1/Smads Pathways
por: Yang, Hun Yong, et al.
Publicado: (2019)

The hirudin-like factors HLF3 and HLF4—hidden hirudins of European medicinal leeches
por: Müller, Christian, et al.
Publicado: (2020)

Astragaloside IV Synergizing with Ferulic Acid Ameliorates Pulmonary Fibrosis by TGF-β1/Smad3 Signaling
por: Tong, Jiahuan, et al.
Publicado: (2021)

PPARγ/NF‐κB and TGF‐β1/Smad pathway are involved in the anti‐fibrotic effects of levo‐tetrahydropalmatine on liver fibrosis
por: Yu, Qiang, et al.
Publicado: (2021)

Disruption of Smad7 Promotes ANG II-Mediated Renal Inflammation and Fibrosis via Sp1-TGF-β/Smad3-NF.κB-Dependent Mechanisms in Mice
por: Liu, Guan-Xian, et al.
Publicado: (2013)

Islet transplantation ameliorates diabetes-induced testicular interstitial fibrosis and is associated with inhibition of TGF-β1/Smad2 pathway in a rat model of type 1 diabetes
por: Zheng, Yuan-Cai, et al.
Publicado: (2021)

TGF-β/Smad signaling in renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2015)

Huoxue Jiedu Huayu Recipe Ameliorates Mesangial Cell Pyroptosis in Contralateral Kidney of UUO Rats
por: Zhang, Yuxuan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jvv6bgmpih20am3ful8g67dgf2