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NLRC4 inflammasome activation is NLRP3- and phosphorylation-independent during infection and does not protect from melanoma

The NAIP/NLRC4 inflammasome is a cytosolic sensor of bacteria that activates caspase-1 and initiates potent immune responses. Structural, biochemical, and genetic data demonstrate that NAIP proteins are receptors for bacterial ligands, while NLRC4 is a downstream adaptor that multimerizes with NAIPs...

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Detalles Bibliográficos
Autores principales:	Tenthorey, Jeannette L., Chavez, Roberto A., Thompson, Thornton W., Deets, Katherine A., Vance, Russell E., Rauch, Isabella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336302/ https://www.ncbi.nlm.nih.gov/pubmed/32342103 http://dx.doi.org/10.1084/jem.20191736

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