Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation

Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1. Consequently, loss of RIPK1 in keratinocytes induces ZBP1-dependent necroptosis and s...

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Detalles Bibliográficos
Autores principales: Devos, Michael, Tanghe, Giel, Gilbert, Barbara, Dierick, Evelien, Verheirstraeten, Maud, Nemegeer, Josephine, de Reuver, Richard, Lefebvre, Sylvie, De Munck, Jolien, Rehwinkel, Jan, Vandenabeele, Peter, Declercq, Wim, Maelfait, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336309/
https://www.ncbi.nlm.nih.gov/pubmed/32315377
http://dx.doi.org/10.1084/jem.20191913

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