ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease

ZBP1 triggers NLRP3 inflammasome activation/pyroptosis, apoptosis, and necroptosis; the specific ligand for ZBP1 activation remains ambiguous. Recent studies, including Devos et al. in this issue of JEM (https://doi.org/10.1084/jem.20191913), collectively suggest that ZBP1 sensing Z-nucleic acids is...

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Detalles Bibliográficos
Autores principales: Kesavardhana, Sannula, Kanneganti, Thirumala-Devi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336316/
https://www.ncbi.nlm.nih.gov/pubmed/32584411
http://dx.doi.org/10.1084/jem.20200885
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author Kesavardhana, Sannula
Kanneganti, Thirumala-Devi
author_facet Kesavardhana, Sannula
Kanneganti, Thirumala-Devi
author_sort Kesavardhana, Sannula
collection PubMed
description ZBP1 triggers NLRP3 inflammasome activation/pyroptosis, apoptosis, and necroptosis; the specific ligand for ZBP1 activation remains ambiguous. Recent studies, including Devos et al. in this issue of JEM (https://doi.org/10.1084/jem.20191913), collectively suggest that ZBP1 sensing Z-nucleic acids is critical for cell death/inflammatory disease.
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spelling pubmed-73363162021-01-06 ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease Kesavardhana, Sannula Kanneganti, Thirumala-Devi J Exp Med Insights ZBP1 triggers NLRP3 inflammasome activation/pyroptosis, apoptosis, and necroptosis; the specific ligand for ZBP1 activation remains ambiguous. Recent studies, including Devos et al. in this issue of JEM (https://doi.org/10.1084/jem.20191913), collectively suggest that ZBP1 sensing Z-nucleic acids is critical for cell death/inflammatory disease. Rockefeller University Press 2020-06-25 /pmc/articles/PMC7336316/ /pubmed/32584411 http://dx.doi.org/10.1084/jem.20200885 Text en © 2020 Kesavardhana and Kanneganti http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Kesavardhana, Sannula
Kanneganti, Thirumala-Devi
ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease
title ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease
title_full ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease
title_fullStr ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease
title_full_unstemmed ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease
title_short ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease
title_sort zbp1: a stargᐰte to decode the biology of z-nucleic acids in disease
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336316/
https://www.ncbi.nlm.nih.gov/pubmed/32584411
http://dx.doi.org/10.1084/jem.20200885
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